人在氧化亚氮麻醉期间丙泊酚输注的剂量需求。II：用劳拉西泮进行术前用药的患者。

Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. II: Patients premedicated with lorazepam.

作者信息

Turtle M J, Cullen P, Prys-Roberts C, Coates D, Monk C R, Faroqui M H

出版信息

Br J Anaesth. 1987 Mar;59(3):283-7. doi: 10.1093/bja/59.3.283.

DOI:10.1093/bja/59.3.283

Abstract

The infusion rate of propofol required to supplement 67% nitrous oxide in oxygen to maintain surgical anaesthesia was determined in 72 patients premedicated with lorazepam. Following an induction dose of propofol 2 mg kg-1, groups of eight patients received an infusion of propofol varying from 60 to 200 micrograms kg-1 min-1. Probit analysis was used to determine the ED50 (130 micrograms kg-1 min-1; 95% confidence limits: 106-167 micrograms kg-1 min-1) and ED95 (348 micrograms kg-1 min-1; 95% confidence limits: 233-1296 micrograms kg-1 min-1) for propofol infusion. Whole blood propofol concentrations at the time of surgical incision correlated strongly with the infusion rate, giving an EC50 value of 2.5 micrograms ml-1, and an EC95 value of 5.92 micrograms ml-1. There was no significant correlation between the rate of infusion of propofol, or the total propofol dose, and the times to response to command, or to recall of birthdate.

摘要

在72例接受劳拉西泮术前用药的患者中，测定了补充67%氧化亚氮-氧气混合气体以维持手术麻醉所需的丙泊酚输注速率。给予2mg/kg的丙泊酚诱导剂量后，每组8例患者接受60至200μg/kg/min的丙泊酚输注。采用概率分析确定丙泊酚输注的ED50（130μg/kg/min；95%置信区间：106 - 167μg/kg/min）和ED95（348μg/kg/min；95%置信区间：233 - 1296μg/kg/min）。手术切口时的全血丙泊酚浓度与输注速率密切相关，EC50值为2.5μg/ml，EC95值为5.92μg/ml。丙泊酚输注速率或丙泊酚总剂量与对指令反应时间或出生日期回忆时间之间无显著相关性。