添加糖的摄入量与心包脂肪组织体积有关。
Added sugar intake is associated with pericardial adipose tissue volume.
机构信息
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, USA.
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center USA.
出版信息
Eur J Prev Cardiol. 2020 Dec;27(18):2016-2023. doi: 10.1177/2047487320931303. Epub 2020 Jun 28.
AIM
The purpose of this study was to determine the relationships of pericardial adipose tissue and visceral adipose tissue volume with added sugar and sugar-sweetened beverage intakes. We hypothesized that both added sugar and sugar-sweetened beverages were positively associated with pericardial adipose tissue and visceral adipose tissue volumes in black and white men and women enrolled in the prospective Coronary Artery Risk Development in Young Adults study.
METHODS AND RESULTS
Dietary intake was assessed by diet history at baseline, year 7 and year 20 examinations in 3070 participants aged 18-30 and generally healthy at baseline. After 25 years follow-up, participants underwent a computed tomography scan of chest and abdomen; the computed tomography scans were read, and pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes were calculated. Quintiles were created for the average of baseline, year 7 and year 20 added sugar and for the average of sugar-sweetened beverages. General linear regression analysis evaluated the associations of pericardial adipose tissue and visceral adipose tissue volumes across quintiles of added sugar and across quintiles of sugar-sweetened beverage intakes adjusted for potential confounding factors. In a multivariable model, pericardial adipose tissue volume was higher across increasing quintiles of added sugar and sugar-sweetened beverage intakes ( = 0.001 and < 0.001, respectively). A similar relation was observed for visceral adipose tissue ( < 0.001 for both added sugar and sugar-sweetened beverages).
CONCLUSIONS
Long-term intakes of added sugar and sugar-sweetened beverages were associated with higher pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes. Because these ectopic fat depots are associated with greater risk of disease incidence, these findings support limiting intakes of added sugar and sugar-sweetened beverages.
目的
本研究旨在确定心包脂肪组织和内脏脂肪组织体积与添加糖和含糖饮料摄入量的关系。我们假设，在参加前瞻性的年轻人冠状动脉风险发展研究的黑人和白人男性和女性中，添加糖和含糖饮料均与心包脂肪组织和内脏脂肪组织体积呈正相关。
方法和结果
在 3070 名年龄在 18-30 岁且基线时一般健康的参与者中，通过基线、第 7 年和第 20 年的饮食史评估饮食摄入。经过 25 年的随访，参与者接受了胸部和腹部的计算机断层扫描；对计算机断层扫描进行了阅读，并计算了心包脂肪组织、内脏脂肪组织和皮下脂肪组织的体积。根据基线、第 7 年和第 20 年添加糖的平均值以及含糖饮料的平均值创建了五分位数。一般线性回归分析评估了在心包脂肪组织和内脏脂肪组织体积方面，随着添加糖的五分位数和含糖饮料摄入量的五分位数的变化而变化的情况，同时调整了潜在的混杂因素。在多变量模型中，随着添加糖和含糖饮料摄入量的五分位数增加，心包脂肪组织体积也随之增加（分别为=0.001 和<0.001）。对于内脏脂肪组织，也观察到了类似的关系（添加糖和含糖饮料均<0.001）。
结论
长期摄入添加糖和含糖饮料与更高的心包脂肪组织、内脏脂肪组织和皮下脂肪组织体积有关。由于这些异位脂肪沉积与更大的疾病发病率风险相关，因此这些发现支持限制添加糖和含糖饮料的摄入量。
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