人工甜味饮料和含糖饮料的累积摄入量与年轻人 2 型糖尿病发病风险的关系：冠状动脉风险发展在年轻人（CARDIA）研究。
Cumulative intake of artificially sweetened and sugar-sweetened beverages and risk of incident type 2 diabetes in young adults: the Coronary Artery Risk Development In Young Adults (CARDIA) Study.
机构信息
Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, MN, USA.
出版信息
Am J Clin Nutr. 2019 Sep 1;110(3):733-741. doi: 10.1093/ajcn/nqz154.
BACKGROUND
Epidemiological evidence has demonstrated a positive association between artificially sweetened beverage (ASB) and sugar-sweetened beverage (SSB) consumption and type 2 diabetes (T2D) risk. However, research informing this topic in young adults is limited.
OBJECTIVE
This study examined the association between ASB, SSB, and total sweetened beverage (TSB; combined ASB and SSB) consumption and T2D risk in young adults.
METHODS
A prospective analysis of 4719 Black and White men and women aged 18-30 y at baseline was conducted from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Each participant's beverage intake was assessed using the CARDIA Diet History at baseline and at study Years 7 and 20. Multivariable Cox proportional hazards regression models were used to examine cumulative average ASB, SSB, and TSB intakes and risk of T2D.
RESULTS
During the 30-y follow-up period, 680 participants developed T2D. ASB consumption was associated with a 12% greater risk of T2D per serving/day (HR 1.12, 95% CI 1.04-1.20) in a model adjusted for lifestyle factors, diet quality, and dieting behavior. Further adjustments for baseline BMI (HR 1.07, 95% CI 0.99-1.14) and weight change during follow-up (HR 1.04, 95% CI 0.97-1.12) attenuated the association. SSB and TSB consumption as continuous variables per 1 serving/day of intake were associated with 6% and 5% increased risks of T2D, respectively (HRSSB 1.06, 95% CI 1.01-1.10; HRTSB 1.05, 95% CI 1.01-1.09), in the model accounting for lifestyle factors, dieting behavior, baseline BMI, and weight change. Results were consistent when the exposures were modeled in categories of consumption and quintiles.
CONCLUSIONS
In young adults, long-term ASB, SSB, and TSB consumption were associated with increased risks of T2D. However, the estimates for ASB were attenuated when accounting for weight changes.
背景
流行病学证据表明，人工甜味饮料（ASB）和含糖饮料（SSB）的摄入与 2 型糖尿病（T2D）风险呈正相关。然而，目前关于这一主题的研究在年轻人中较为有限。
目的
本研究旨在探讨年轻人中 ASB、SSB 和总含糖饮料（TSB；ASB 和 SSB 之和）的摄入与 T2D 风险之间的关系。
方法
对来自冠状动脉风险发展在年轻人（CARDIA）研究中的 4719 名年龄在 18-30 岁的黑人和白人进行了前瞻性分析。每位参与者的饮料摄入量通过 CARDIA 饮食史在基线和研究第 7 年和第 20 年进行评估。多变量 Cox 比例风险回归模型用于检测累积平均 ASB、SSB 和 TSB 摄入量与 T2D 的风险。
结果
在 30 年的随访期间，680 名参与者患上了 T2D。在调整生活方式因素、饮食质量和节食行为的模型中，ASB 摄入量每增加一份/天，T2D 的风险增加 12%（HR 1.12，95%CI 1.04-1.20）。进一步调整基线 BMI（HR 1.07，95%CI 0.99-1.14）和随访期间体重变化（HR 1.04，95%CI 0.97-1.12）后，该关联减弱。SSB 和 TSB 作为连续变量，每摄入 1 份/天，分别与 T2D 风险增加 6%和 5%相关（HRSSB 1.06，95%CI 1.01-1.10；HRTSB 1.05，95%CI 1.01-1.09），该模型考虑了生活方式因素、节食行为、基线 BMI 和体重变化。当将暴露因素按摄入量分类和五分位数进行建模时，结果是一致的。
结论
在年轻人中，长期摄入 ASB、SSB 和 TSB 与 T2D 风险增加相关。然而，当考虑体重变化时，ASB 的估计值会减弱。
Zotero 插件