Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province, Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China.
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co. Ltd, Jiangsu, Lianyungang, China.
Nat Prod Res. 2022 Jan;36(1):186-192. doi: 10.1080/14786419.2020.1775227. Epub 2020 Jun 27.
Two new iridoid glycosides, 2'---coumaroylgardoside (), and 6'--caffeoylioxide (), were isolated from the fruit of . The structures of these compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR) and chemical methods. The anti-inflammatory activities of the isolates were evaluated by measuring their inhibitory effects on PGE production in LPS stimulated RAW 264.7 macrophages, compounds and could reduce PGE levels in LPS-activated RAW 264.7 macrophages with IC values of 121.4 and 83.38 μ, respectively.
从 果实中分离得到了两个新的裂环环烯醚萜糖苷：2'-对香豆酰基牡荆苷（）和 6'-咖啡酰氧基氧化槐定碱（）。基于光谱分析（高分辨电喷雾质谱，NMR）和化学方法确定了这些化合物的结构。通过测量对 LPS 刺激的 RAW 264.7 巨噬细胞中 PGE 产生的抑制作用来评估分离物的抗炎活性，化合物和可以分别以 121.4 和 83.38 μ 的 IC 值降低 LPS 激活的 RAW 264.7 巨噬细胞中的 PGE 水平。
