Hao Ya, Wang Jianhua, Teng Da, Wang Xiumin, Mao Ruoyu, Yang Na, Ma Xuanxuan
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, P.R. China.
Biochem Cell Biol. 2021 Feb;99(1):66-72. doi: 10.1139/bcb-2020-0078. Epub 2020 Jun 27.
Piglets, especially weaning piglets, show a lower level of immunity and higher morbidity and mortality, owing to their rapid growth, physiological immaturity, and gradual reduction of maternal antibodies, which seriously affects their growth and thus, value. It is important that piglets adapt to nutrient digestion and absorption and develop sound intestinal function and colonization with gut microbiota as soon as possible during their early life stage. Lactoferrin is a natural glycoprotein polypeptide that is part of the transferrin family. It is widely found in mucosal secretions such as saliva and tears, and most highly in milk and colostrum. As a multifunctional bioactive protein and a recommended food additive, lactoferrin is a potential alternative therapy to antibiotics and health promoting additive for piglet nutrition and development. It is expected that lactoferrin, as a natural food additive, could play an important role in maintaining pig health and development. This review examines the following known beneficial effects of lactoferrin: improves the digestion and capacity for absorption in the intestinal tract; promotes the absorption of iron and reduces the incidence of iron deficiency anemia; regulates intestinal function and helps to balance the microbial biota; and enhances the resistance to disease of the piglets via modulating and enhancing the immune system.
仔猪，尤其是断奶仔猪，由于其生长迅速、生理不成熟以及母源抗体逐渐减少，免疫力较低，发病率和死亡率较高，这严重影响了它们的生长，进而影响其价值。重要的是，仔猪在生命早期阶段应尽快适应营养物质的消化和吸收，并发展良好的肠道功能以及建立肠道微生物群定植。乳铁蛋白是转铁蛋白家族的一种天然糖蛋白多肽。它广泛存在于唾液和眼泪等黏膜分泌物中，在牛奶和初乳中含量最高。作为一种多功能生物活性蛋白和推荐的食品添加剂，乳铁蛋白是抗生素的潜在替代疗法，也是促进仔猪营养和发育的健康添加剂。预计乳铁蛋白作为一种天然食品添加剂，在维持猪的健康和发育方面可发挥重要作用。本综述探讨了乳铁蛋白以下已知的有益作用：改善肠道消化和吸收能力；促进铁的吸收并降低缺铁性贫血的发生率；调节肠道功能并有助于平衡微生物群；通过调节和增强免疫系统提高仔猪的抗病能力。
