Vlassara H, Brownlee M, Manogue K R, Dinarello C A, Pasagian A
Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021.
Science. 1988 Jun 10;240(4858):1546-8. doi: 10.1126/science.3259727.
Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.
随着时间的推移，蛋白质会与葡萄糖发生一系列非酶促反应，形成晚期糖基化终产物（AGEs）。巨噬细胞有一种受体，可识别AGE部分，并介导AGE蛋白的摄取和降解。这个清除过程与恶病质素（肿瘤坏死因子）和白细胞介素-1的产生和分泌有关，这两种细胞因子具有多样且看似矛盾的生物学活性。这些细胞因子的局部释放和作用可以解释在正常组织稳态中衰老细胞外基质成分的协同清除和替代。
