Institute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, China.
Department of Radiology, Lishui Hospital of Zhejiang University, Lishui 323000, China.
ACS Appl Mater Interfaces. 2020 Jul 22;12(29):32372-32387. doi: 10.1021/acsami.0c07503. Epub 2020 Jul 8.
A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse and metastasis. During this research, multifunctional upconversion nanoparticles (UCNPs) coated by ROS-responsive micelles are prepared for tumor targeting and near-infrared (NIR)-triggered photodynamic therapy (PDT)-combined synergistic effect of chemotherapy. Moreover, both PDT and chemotherapy agents could activate antitumor immunity inducing immunogenic cell death with CD8 and CD4 T cells infiltrating in tumors. Through the experiments, intravenous administration of multifunctional nanocarriers with noninvasive NIR irradiation destroys the orthotopic tumors and efficiently suppresses lung metastasis in a metastatic triple-negative breast cancer model by cascade-amplifying chemo-PDT and systemic antitumor immunity. In conclusion, this study provides prospective chemo-PDT with inspired antitumor immunity for metastatic cancer treatment.
一种理想的癌症治疗策略不仅应具有最大的抗癌能力，还应激发抗肿瘤免疫，以预防肿瘤复发和转移。在这项研究中，制备了由 ROS 响应胶束包覆的多功能上转换纳米粒子（UCNPs），用于肿瘤靶向和近红外（NIR）触发光动力疗法（PDT）与化疗的协同作用。此外，PDT 和化疗药物都可以通过 CD8 和 CD4 T 细胞浸润肿瘤来诱导免疫原性细胞死亡，从而激活抗肿瘤免疫。通过实验，静脉注射多功能纳米载体，并进行非侵入性的近红外辐射，通过级联放大的化疗-PDT 和全身抗肿瘤免疫，破坏原位肿瘤，并有效地抑制转移性三阴性乳腺癌模型中的肺转移。总之，这项研究为转移性癌症治疗提供了具有启发意义的抗肿瘤免疫的化疗-PDT 新策略。
