Xiangya Hospital, Central South University, Changsha, China.
Xiangya Nursing School, Central South University, Changsha, China.
Int J Sports Med. 2020 Oct;41(12):815-823. doi: 10.1055/a-1186-1272. Epub 2020 Jun 29.
This study investigated the benefits of resistance training on cognition in patients with mild cognitive impairment. We searched the PubMed, Embase and Cochrane Library databases, and seven randomized controlled trials were reviewed. We evaluated the risk of bias using the Cochrane Collaboration's bias assessment tool. Standard mean differences with 95% confidence intervals were calculated for statistical analysis. This meta-analysis assessed three variables: general cognitive function, executive function and working memory. The results indicate that general cognitive function improved significantly (standardized mean difference: 0.53, P=0.04), and further subgroup analyses on frequency and duration per session showed that the subgroups 'twice a week' (P=0.01) and 'duration per session 60 min' (P=0.0006) exhibited better performance than the subgroups 'three time a week' (P=0.47) and 'duration per session <60 min' (P=0.53). Additionally, a moderate effect size was found in executive function (standardized mean difference: 0.50, P=0.0003), and there was non-significant effect in working memory (P=0.14). In summary, resistance training may mitigate mild cognitive impairment by improving cognition. Larger-scale studies are recommended to demonstrate the relationship between resistance training and cognition in mild cognitive impairment.
本研究探讨了抗阻训练对轻度认知障碍患者认知功能的益处。我们检索了 PubMed、Embase 和 Cochrane Library 数据库，共纳入了 7 项随机对照试验。我们使用 Cochrane 协作偏倚评估工具评估了风险偏倚。采用标准化均数差及其 95%置信区间进行统计学分析。本荟萃分析评估了 3 个变量：一般认知功能、执行功能和工作记忆。结果表明，一般认知功能显著改善（标准化均数差：0.53，P=0.04），进一步对频率和每次疗程持续时间的亚组分析显示，每周 2 次（P=0.01）和每次疗程 60 分钟（P=0.0006）亚组的表现优于每周 3 次（P=0.47）和每次疗程<60 分钟（P=0.53）亚组。此外，在执行功能方面发现了中等效应量（标准化均数差：0.50，P=0.0003），而在工作记忆方面没有显著效果（P=0.14）。综上所述，抗阻训练可能通过改善认知来减轻轻度认知障碍。建议开展更大规模的研究，以进一步明确抗阻训练与轻度认知障碍患者认知功能之间的关系。
