Ogłuszka Magdalena, Te Pas Marinus F W, Poławska Ewa, Nawrocka Agata, Stepanow Kamila, Pierzchała Mariusz
Department of Genomics and Biodiversity, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland.
Animal Breeding and Genomics, Wageningen UR Livestock Research, 6700AH Wageningen, The Netherlands.
Animals (Basel). 2020 Jun 24;10(6):1090. doi: 10.3390/ani10061090.
Omega-3 fatty acids are health-promoting nutrients that contribute to the amelioration of age-related diseases. Recent studies have reported the role of these fatty acids in the aging process, explicitly impacting telomere biology. The shelterin protein complex, located at the extremities of chromosomes, ensures telomere protection and length regulation. Here, we analyzed the impact of dietary omega-3 alpha-linolenic fatty acid from linseed oil on skeletal muscle telomere biology using an animal model of female pigs. Fifteen animals were supplemented with linseed oil for nine weeks and an equal number of individuals were fed with a control diet. Linseed-oil-supplemented animals showed an increased level of alpha-linolenic acid in skeletal muscles compared to control animals. There was no difference between groups in the telomere length measured in leukocytes and muscles. However, muscles of the linseed-oil-supplemented pigs showed lower levels of the shelterin TRF1 protein compared to the control group. Our results suggest that omega-3 linolenic acid counteracts the elevation of TRF1 levels, which increase with age and due to the presence of reactive oxygen species in muscle. The observed effect may be due to attenuation of oxidative stress.
欧米伽-3脂肪酸是促进健康的营养物质，有助于改善与年龄相关的疾病。最近的研究报道了这些脂肪酸在衰老过程中的作用，明确影响端粒生物学。位于染色体末端的端粒保护蛋白复合体可确保端粒的保护和长度调节。在此，我们使用雌性猪的动物模型分析了亚麻籽油中膳食欧米伽-3α-亚麻酸对骨骼肌端粒生物学的影响。15只动物补充亚麻籽油9周，相同数量的个体喂食对照饮食。与对照动物相比，补充亚麻籽油的动物骨骼肌中α-亚麻酸水平升高。白细胞和肌肉中端粒长度的测量在两组之间没有差异。然而，与对照组相比，补充亚麻籽油的猪的肌肉中 shelterin TRF1蛋白水平较低。我们的结果表明，欧米伽-3亚麻酸可抵消TRF1水平的升高，TRF1水平会随着年龄增长以及肌肉中活性氧的存在而增加。观察到的效果可能是由于氧化应激的减弱。
