西班牙前列腺癌的最新趋势。

Recent trends in prostate cancer in Spain.

机构信息

Departamento de Medicina Interna, Hospital Severo Ochoa, Leganés, España.

Unidad de Urología Oncología, UGC Urología-Nefrología, Hospital Universitario Virgen del Rocío, Sevilla, España.

出版信息

Actas Urol Esp (Engl Ed). 2020 Sep;44(7):483-488. doi: 10.1016/j.acuro.2020.05.003. Epub 2020 Jun 26.

DOI:10.1016/j.acuro.2020.05.003

PMID:32600879

Abstract

OBJECTIVE

To assess recent trends in prostate cancer incidence, survival and mortality in Spain using updated data.

SUBJECTS AND METHOD

Prostate cancer mortality data have been obtained from the National Institute of Statistics (INE). Incidence cases have been obtained from the databases Cancer Incidence in Five Continents (CI5) and European Cancer Information System. Joinpoint regression models were used for trend analysis. The results show the duration (years) of each trend, as well as the Annual Percent Change (APC) for each of them. The direction and magnitude of recent trends (last 5 years available) were evaluated using the percentages of Average Annual Percent Change (AAPC).

RESULTS

Incidence rates increased significantly from 16.4 in 1980 to 61.3 in 2014. The joinpoint analysis shows three periods: two initial periods of significant rise (1980-1990; 3.5% and 1990-2004; 8.4%) followed by a final one in which rates stabilize (2004-2014; -0.5%, non-significant). Mortality rates drop from 12.9 in 1980 to 7.9 in 2018, with an AAPC of -1.2% (p<0.05). However, the joinpoint analysis identified three time periods: an initial period of statistically significant rise (1980-1998; APC: 0.6%, p<0.05) and two periods of decreasing rates (1992-2008; APC: -3.3%, p<0.05 and 2008-2018; APC: -2.4%, p<0.05).

CONCLUSION

Recent trends (last 5 years) show that mortality rates have decreased and incidence rates have stabilized or even decreased in some age groups.

摘要

目的

使用最新数据评估西班牙前列腺癌发病率、生存率和死亡率的近期趋势。

对象与方法

国家统计局（INE）提供了前列腺癌死亡率数据。癌症发病率数据库（CI5）和欧洲癌症信息系统（EIS）提供了发病率数据。采用 Joinpoint 回归模型进行趋势分析。结果显示了每种趋势的持续时间（年），以及每种趋势的年平均变化百分比（APC）。使用平均年平均变化百分比（AAPC）评估最近趋势（最后 5 年可用）的方向和幅度。

结果

发病率从 1980 年的 16.4 显著上升至 2014 年的 61.3。Joinpoint 分析显示有三个时期：两个最初的显著上升时期（1980-1990 年；3.5%和 1990-2004 年；8.4%），随后是一个稳定时期（2004-2014 年；-0.5%，无统计学意义）。死亡率从 1980 年的 12.9 下降至 2018 年的 7.9，AAPC 为-1.2%（p<0.05）。然而，Joinpoint 分析确定了三个时期：一个最初的统计学上显著上升时期（1980-1998 年；APC：0.6%，p<0.05）和两个下降时期（1992-2008 年；APC：-3.3%，p<0.05 和 2008-2018 年；APC：-2.4%，p<0.05）。