Karvonen M J
Bull World Health Organ. 1988;66(1):7-14.
Cardiovascular diseases are a major cause of mortality, morbidity and disability of the elderly in both developed and developing countries. Their prevention has two aims: to add life to years and years to life. Observational studies suggest that the risk factors for these diseases in the middle-aged predict their incidence and the mortality due to them among the elderly. Direct evidence on the effectiveness of prevention by controlling these risk factors in the elderly, however, is still largely lacking or inconclusive. Nevertheless, the recent falling mortality trends in several countries indicate that deaths due to cardiovascular diseases can decrease rapidly also among the elderly, although the causes of the trends are not yet all clear. The very large cross-national differences in mortality from coronary heart disease and cerebrovascular diseases are a challenge for the wider application of preventive measures now. For the control of some risk factors, particularly of high blood pressure, further research focused on the elderly is urgently needed.
心血管疾病是发达国家和发展中国家老年人死亡、发病和残疾的主要原因。其预防有两个目标:延长寿命并提高生活质量。观察性研究表明,中年时期这些疾病的危险因素可预测其在老年人中的发病率和死亡率。然而,关于通过控制老年人这些危险因素进行预防的有效性的直接证据仍然大多缺乏或不确定。尽管如此,最近几个国家死亡率下降的趋势表明,心血管疾病导致的死亡在老年人中也可以迅速减少,尽管这些趋势的原因尚未完全明确。冠心病和脑血管疾病死亡率存在极大的跨国差异,这对目前更广泛地应用预防措施构成了挑战。为了控制某些危险因素,尤其是高血压,迫切需要针对老年人开展进一步研究。