College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Tea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, PR China.
J Agric Food Chem. 2023 Oct 18;71(41):14853-14869. doi: 10.1021/acs.jafc.3c03923. Epub 2023 Oct 10.
Dietary fiber is a carbohydrate polymer with ten or more monomeric units that are resistant to digestion by human digestive enzymes, and it has gained widespread attention due to its significant role in health improvement through regulating gut microbiota. In this review, we summarized the interaction between dietary fiber, gut microbiota, and obesity, and the beneficial effects of dietary fiber on obesity through the modulation of microbiota, such as modifying selective microbial composition, producing starch-degrading enzymes, improving gut barrier function, reducing the inflammatory response, reducing trimethylamine N-oxide, and promoting the production of gut microbial metabolites (e.g., short chain fatty acids, bile acids, ferulic acid, and succinate). In addition, factors affecting the gut microbiota composition and metabolites by dietary fiber (length of the chain, monosaccharide composition, glycosidic bonds) were also concluded. Moreover, strategies for enhancing the biological activity of dietary fiber (fermentation technology, ultrasonic modification, nanotechnology, and microfluidization) were subsequently discussed. This review may provide clues for deeply exploring the structure-activity relationship between dietary fiber and antiobesity properties by targeting specific gut microbiota.
膳食纤维是一种由十个或更多单体单元组成的碳水化合物聚合物，其不能被人体消化酶消化，由于其通过调节肠道微生物群在改善健康方面的重要作用，已引起广泛关注。在这篇综述中，我们总结了膳食纤维、肠道微生物群和肥胖之间的相互作用，以及膳食纤维通过调节微生物群对肥胖的有益影响，例如改变选择性微生物组成、产生淀粉降解酶、改善肠道屏障功能、减少炎症反应、降低三甲基胺 N-氧化物含量以及促进肠道微生物代谢物（例如短链脂肪酸、胆汁酸、阿魏酸和琥珀酸）的产生。此外，还总结了膳食纤维影响肠道微生物群组成和代谢物的因素（链长、单糖组成、糖苷键）。此外，还随后讨论了增强膳食纤维生物活性的策略（发酵技术、超声改性、纳米技术和微流化）。这篇综述可能为通过靶向特定肠道微生物群深入探索膳食纤维与抗肥胖特性之间的结构-活性关系提供线索。
