Centre for Applied Research, Innovation and Entrepreneurship Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada.
Prog Lipid Res. 2020 Jul;79:101048. doi: 10.1016/j.plipres.2020.101048. Epub 2020 Jun 27.
In this review, steroids with a tertiary butyl group, which are usually called neo steroids, are a small group of natural lipids isolated from higher plants, fungi, marine sponges, and yeast. In addition, steroids with a tertiary butyl group have been synthesized in some laboratories in Canada, USA, Europe, and Japan and their biological activity was studied. Some natural neo steroids demonstrate antitumor or hepatoprotective activities. In addition, synthetic neo steroids exhibit anticancer and neuroprotective properties. However, to confirm the above data, both practical and clinical experimental studies are necessary. Nevertheless, the results may be useful for pharmacologists, chemists, biochemists, and the pharmaceutical industry.
在这篇综述中，三级丁基取代的甾体，通常被称为新甾体，是从小麦、真菌、海绵和酵母等高等植物中分离出来的一组天然脂质。此外，加拿大、美国、欧洲和日本的一些实验室也合成了三级丁基取代的甾体，并研究了它们的生物活性。一些天然的新甾体具有抗肿瘤或保肝活性。此外，合成的新甾体具有抗癌和神经保护作用。然而，为了证实上述数据，还需要进行实际和临床实验研究。尽管如此，这些结果可能对药理学家、化学家、生物化学家以及制药工业都有一定的帮助。
