N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991, Moscow, Russia.
Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South Lethbridge, AB, T1K 1L6, Canada.
J Steroid Biochem Mol Biol. 2019 Jun;190:76-87. doi: 10.1016/j.jsbmb.2019.03.020. Epub 2019 Mar 25.
Hydroperoxides (R-OOH) represent a small family of natural metabolites that have been isolated from higher plants, fungi, and marine organisms. This paper is devoted to the distribution of hydroperoxides in plants, fungi and terrestrial fungal endophytes and their biological activity. Hydroperoxides of plants demonstrate a wide range of biological activities however, antineoplastic and anti-ulcerative are most characteristic with confidence from 91 to 98 percent. For hydroperoxides from fungi, the dominant are antineoplastic and anti-hypercholesterolemic activities with confidence from 89 to 92 percent. Very interesting activity was found for some triterpenoid hydroperoxides, which is characterized as a treatment for the symptoms of dementia. The norlupane hydroperoxide shows activity for the treatment of dementia. It is interesting that the reliability of this activity was very high 97.2%. According to our preliminary data, the norlupane hydroperoxide is apparently the first natural metabolite that showed almost 100 percent activity for the treatment of dementia. However, to confirm these data requires practical and clinical experimental work.
氢过氧化物（R-OOH）代表了一小类天然代谢产物，已从高等植物、真菌和海洋生物中分离出来。本文致力于研究氢过氧化物在植物、真菌和陆地真菌内生菌中的分布及其生物活性。植物氢过氧化物表现出广泛的生物活性，但具有抗肿瘤和抗溃疡活性，置信度为 91%至 98%。对于真菌中的氢过氧化物，具有抗肿瘤和降胆固醇活性的占主导地位，置信度为 89%至 92%。一些三萜类氢过氧化物具有非常有趣的活性，可用于治疗痴呆症症状。诺鲁烷氢过氧化物具有治疗痴呆症的活性。有趣的是，这种活性的可靠性非常高，为 97.2%。根据我们的初步数据，诺鲁烷氢过氧化物显然是第一种表现出几乎 100%治疗痴呆症活性的天然代谢产物。然而，要证实这些数据还需要进行实际和临床实验工作。
