Center for Drug Delivery Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, United States.
Dermatologist, Frimley Park Hospital NHS Foundation Trust, Frimley, Surrey, United Kingdom.
Int J Pharm. 2020 Aug 30;586:119584. doi: 10.1016/j.ijpharm.2020.119584. Epub 2020 Jun 27.
Iontophoretic transdermal delivery uses a small electric current to push charged molecules into the skin under an electrode of same polarity and offers an attractive option to facilitate the delivery of macromolecules or hydrophilic molecules and to improve patient compliance. This technique has been used in physical therapy clinics for several decades, though the science was not always there to support claims of clinical effectiveness. Recently, this modality of treatment has undergone more systematic and rigorous investigations to withstand the scrutiny of regulatory authorities. In recent years various drugs have gained FDA approval for iontophoretic patches. This technique is gaining recognition due to better compliance rates, non-invasive drug delivery leading to fewer side effects, and sustained release of the drug. Furthermore, programmed delivery and bolus delivery systems have helped with customizing the drug dosage and frequency of dosage based on the patient's need.
电渗透透皮递送技术利用小电流将带电荷的分子推送至相同极性的电极下的皮肤中，为促进大分子或亲水分子的递送以及提高患者顺应性提供了一种有吸引力的选择。这种技术已经在物理治疗诊所使用了几十年，尽管科学并不总是能够支持临床有效性的说法。最近，这种治疗方式已经接受了更系统和严格的调查，以经受监管机构的严格审查。近年来，各种药物已获得 FDA 批准用于电渗透贴片。由于更好的顺应性、非侵入性药物递送导致更少的副作用以及药物的持续释放，这种技术得到了认可。此外，编程递送和推注递送系统有助于根据患者的需求定制药物剂量和给药频率。
