慢性肝脏疾病中的虚弱与抑郁状态密切相关。

Close Correlation between Frailty and Depressive State in Chronic Liver Diseases.

机构信息

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.

Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.

出版信息

Medicina (Kaunas). 2020 Jun 27;56(7):319. doi: 10.3390/medicina56070319.

DOI:10.3390/medicina56070319

PMID:32605049

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7404642/

Abstract

BACKGROUND AND OBJECTIVES

Few data with regard to the relevance between depression and frailty in chronic liver disease (CLD) patients are currently available. We aimed to elucidate the relationship between frailty and depression as evaluated by the Beck Depression Inventory-2nd edition (BDI-II) in CLD patients ( = 340, median age = 65.0 years).

METHODS

Frailty was defined as a clinical syndrome in which three or more of the following criteria were met: body weight loss, exhaustion, muscle weakness, slow walking speed and low physical activity. Depressive state was defined as BDI-II score 11 or greater.

RESULTS

Robust (frailty score = zero), prefrail (frailty score = one or two) and frailty were identified in 114 (33.5%), 182 (53.5%) and 44 (12.9%). The median BDI-II score was five. Depressive state was identified in 84 patients (24.7%). The median BDI-II scores in patients with robust, prefrail and frail traits were 2, 7 and 12.5 (robust vs. prefrail, < 0.0001; prefrail vs. robust, = 0.0003; robust vs. frail, < 0.0001; overall < 0.0001). The proportions of depressive state in patients with robust, prefrail and frail traits were 3.51%, 30.77% and 54.55% (robust vs. prefrail, < 0.0001; prefrail vs. robust, = 0.0046; robust vs. frail, < 0.0001; overall < 0.0001). BDI-II score significantly correlated with frailty score ( = 0.5855, < 0.0001).

CONCLUSIONS

The close correlation between frailty and depression can be found in CLD. Preventing frailty in CLD should be approached both physiologically and psychologically.

摘要

背景和目的

目前，关于慢性肝脏疾病（CLD）患者的抑郁与虚弱之间相关性的数据较少。我们旨在阐明 CLD 患者中贝克抑郁量表第二版（BDI-II）评估的虚弱与抑郁之间的关系（n=340，中位年龄=65.0 岁）。

方法

虚弱被定义为一种临床综合征，其中满足以下三个或更多标准：体重减轻、疲惫、肌肉无力、行走速度缓慢和体力活动低。抑郁状态定义为 BDI-II 评分≥11。

结果

确定了 114 例（33.5%）、182 例（53.5%）和 44 例（12.9%）的无虚弱（虚弱评分=零）、虚弱前期（虚弱评分=一或二）和虚弱患者。BDI-II 评分中位数为 5。识别出 84 例（24.7%）抑郁状态患者。无虚弱、虚弱前期和虚弱特征患者的 BDI-II 评分中位数分别为 2、7 和 12.5（无虚弱与虚弱前期，<0.0001；虚弱前期与无虚弱，=0.0003；无虚弱与虚弱，<0.0001；总体<0.0001）。无虚弱、虚弱前期和虚弱特征患者的抑郁状态比例分别为 3.51%、30.77%和 54.55%（无虚弱与虚弱前期，<0.0001；虚弱前期与无虚弱，=0.0046；无虚弱与虚弱，<0.0001；总体<0.0001）。BDI-II 评分与虚弱评分显著相关（=0.5855，<0.0001）。