• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肠道微生态移植治疗胃肠道疾病:精准医学的时代。

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine.

机构信息

Service de Maladies Infectieuses, Hôpital de La Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

Université Claude Bernard Lyon 1, Lyon, France.

出版信息

Genome Med. 2020 Jun 30;12(1):58. doi: 10.1186/s13073-020-00757-y.

DOI:10.1186/s13073-020-00757-y
PMID:32605650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7329555/
Abstract

Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating inflammatory bowel diseases and irritable bowel syndrome in an increasing number of randomized controlled trials. Recently published data gives striking insights into the factors associated with FMT success paving the road for the use of precision medicine in gastrointestinal disorders.

摘要

粪便微生物群移植(FMT)在越来越多的随机对照试验中已被证明可有效治疗炎症性肠病和肠易激综合征。最近发表的数据为与 FMT 成功相关的因素提供了引人注目的见解,为胃肠道疾病的精准医学应用铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d047/7329555/acd78ad6018f/13073_2020_757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d047/7329555/acd78ad6018f/13073_2020_757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d047/7329555/acd78ad6018f/13073_2020_757_Fig1_HTML.jpg

相似文献

1
Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine.肠道微生态移植治疗胃肠道疾病:精准医学的时代。
Genome Med. 2020 Jun 30;12(1):58. doi: 10.1186/s13073-020-00757-y.
2
Fecal microbiota transplantation for gastrointestinal diseases.用于胃肠道疾病的粪便微生物群移植
Keio J Med. 2014;63(4):69-74. doi: 10.2302/kjm.2014-0006-RE. Epub 2014 Dec 15.
3
[Current research progress and thinking of fecal microbiota transplantation for the treatment of gastrointestinal disorders].[粪便微生物群移植治疗胃肠道疾病的当前研究进展与思考]
Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Oct 25;20(10):1104-1108.
4
An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases.粪便微生物群移植治疗胃肠道疾病的最新进展。
J Gastroenterol Hepatol. 2022 Feb;37(2):246-255. doi: 10.1111/jgh.15731. Epub 2021 Nov 12.
5
Principles of DNA-Based Gut Microbiota Assessment and Therapeutic Efficacy of Fecal Microbiota Transplantation in Gastrointestinal Diseases.基于DNA的肠道微生物群评估原理及粪便微生物群移植在胃肠道疾病中的治疗效果
Dig Dis. 2016;34(3):279-85. doi: 10.1159/000443362. Epub 2016 Mar 30.
6
[Efficacy analysis of fecal microbiota transplantation in the treatment of 2010 patients with intestinal disorders].[粪便微生物群移植治疗2010例肠道疾病患者的疗效分析]
Zhonghua Wei Chang Wai Ke Za Zhi. 2019 Sep 25;22(9):861-868. doi: 10.3760/cma.j.issn.1671-0274.2019.09.011.
7
The Progression of Microbiome Therapeutics for the Management of Gastrointestinal Diseases and Beyond.肠道微生态治疗学的进展:从胃肠道疾病治疗到其他领域
Gastroenterology. 2024 Oct;167(5):885-902. doi: 10.1053/j.gastro.2024.05.004. Epub 2024 May 14.
8
Abnormal Intestinal Microbiome in Medical Disorders and Potential Reversibility by Fecal Microbiota Transplantation.肠道微生物组在医学疾病中的异常表现和粪便微生物移植的潜在逆转作用。
Dig Dis Sci. 2020 Mar;65(3):741-756. doi: 10.1007/s10620-020-06102-y.
9
Fecal microbiota transplantation in disease therapy.粪便微生物群移植在疾病治疗中的应用。
Clin Chim Acta. 2020 Apr;503:90-98. doi: 10.1016/j.cca.2019.12.010. Epub 2020 Jan 20.
10
Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review.粪菌移植作为胃肠病学的新型疗法:一项系统综述。
World J Gastroenterol. 2015 May 7;21(17):5359-71. doi: 10.3748/wjg.v21.i17.5359.

引用本文的文献

1
Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation.丁酸和戊酸通过抑制海马神经炎症减轻应激诱导的铁死亡和抑郁样行为。
J Transl Med. 2025 Sep 2;23(1):974. doi: 10.1186/s12967-025-06950-0.
2
Gut Microbiota-Derived Acetate Ameliorates Endometriosis via JAK1/STAT3-Mediated M1 Macrophage Polarisation.肠道微生物群衍生的乙酸盐通过JAK1/STAT3介导的M1巨噬细胞极化改善子宫内膜异位症。
Microb Biotechnol. 2025 Aug;18(8):e70202. doi: 10.1111/1751-7915.70202.
3
Feasibility of machine learning-based modeling and prediction to assess osteosarcoma outcomes.

本文引用的文献

1
Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis.真菌跨界动态与溃疡性结肠炎对粪便微生物群移植 (FMT) 治疗的反应性相关。
Cell Host Microbe. 2020 May 13;27(5):823-829.e3. doi: 10.1016/j.chom.2020.03.006. Epub 2020 Apr 15.
2
Fecal microbiota transplantation to maintain remission in Crohn's disease: a pilot randomized controlled study.粪便微生物群移植维持克罗恩病缓解:一项初步随机对照研究。
Microbiome. 2020 Feb 3;8(1):12. doi: 10.1186/s40168-020-0792-5.
3
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study.
基于机器学习的建模和预测评估骨肉瘤预后的可行性。
Sci Rep. 2025 May 19;15(1):17386. doi: 10.1038/s41598-025-00179-z.
4
The effects of repeated fecal transplantation and activated charcoal treatment on gut dysbiosis induced by concurrent ceftriaxone administration in mice.重复粪便移植和活性炭处理对小鼠同时给予头孢曲松所致肠道菌群失调的影响。
Sci Rep. 2025 Apr 22;15(1):13908. doi: 10.1038/s41598-025-96701-4.
5
Fecal Microbiota Transplantation: Insights into Colon Carcinogenesis and Immune Regulation.粪便微生物群移植:对结肠癌发生和免疫调节的见解。
J Clin Med. 2024 Nov 1;13(21):6578. doi: 10.3390/jcm13216578.
6
The Influence of the Gut Microbiota on Host Health: A Focus on the Gut-Lung Axis and Therapeutic Approaches.肠道微生物群对宿主健康的影响:聚焦肠-肺轴及治疗方法
Life (Basel). 2024 Oct 9;14(10):1279. doi: 10.3390/life14101279.
7
Neutrophils: from IBD to the gut microbiota.中性粒细胞:从炎症性肠病到肠道微生物群
Nat Rev Gastroenterol Hepatol. 2024 Mar;21(3):184-197. doi: 10.1038/s41575-023-00871-3. Epub 2023 Dec 18.
8
The New Microbiology: an international lecture course on the island of Spetses.新微生物学:斯佩茨斯岛国际讲座课程
Microlife. 2023 Mar 31;4:uqac026. doi: 10.1093/femsml/uqac026. eCollection 2023.
9
Therapeutic targets in alcohol-associated liver disease: progress and challenges.酒精性肝病的治疗靶点:进展与挑战
Therap Adv Gastroenterol. 2023 May 10;16:17562848231170946. doi: 10.1177/17562848231170946. eCollection 2023.
10
The Gut Microbiome and Pancreatic Cancer Development and Treatment.肠道微生物组与胰腺癌的发生发展和治疗。
Cancer J. 2023;29(2):49-56. doi: 10.1097/PPO.0000000000000647.
在一项随机、双盲、安慰剂对照研究中评估粪便微生物群移植治疗肠易激综合征患者的疗效。
Gut. 2020 May;69(5):859-867. doi: 10.1136/gutjnl-2019-319630. Epub 2019 Dec 18.
4
Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial.粪便微生物群移植治疗腹泻为主型肠易激综合征:一项双盲、随机、安慰剂对照试验。
Lancet Gastroenterol Hepatol. 2019 Sep;4(9):675-685. doi: 10.1016/S2468-1253(19)30198-0. Epub 2019 Jul 17.
5
The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study.异体与自体粪便微生物群移植对肠易激综合征症状、内脏感知及粪便和黏膜微生物群的影响:一项随机对照研究。
Clin Transl Gastroenterol. 2019 Apr;10(4):e00034. doi: 10.14309/ctg.0000000000000034.
6
Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis.与溃疡性结肠炎患者对粪便微生物群移植的反应相关的特定细菌和代谢物。
Gastroenterology. 2019 Apr;156(5):1440-1454.e2. doi: 10.1053/j.gastro.2018.12.001. Epub 2018 Dec 6.
7
Fecal transplantation for treatment of inflammatory bowel disease.粪便移植治疗炎症性肠病。
Cochrane Database Syst Rev. 2018 Nov 13;11(11):CD012774. doi: 10.1002/14651858.CD012774.pub2.
8
Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study.粪便微生物群移植改变肠易激综合征患者的肠道微生物群:一项随机、双盲、安慰剂对照研究的结果。
Gut. 2018 Dec;67(12):2107-2115. doi: 10.1136/gutjnl-2018-316434. Epub 2018 Jul 6.
9
Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial.粪便微生物群移植与安慰剂治疗中重度肠易激综合征的随机双盲对照平行分组单中心试验。
Lancet Gastroenterol Hepatol. 2018 Jan;3(1):17-24. doi: 10.1016/S2468-1253(17)30338-2. Epub 2017 Nov 1.
10
Durable coexistence of donor and recipient strains after fecal microbiota transplantation.粪便微生物群移植后供体和受体菌株的持久共存。
Science. 2016 Apr 29;352(6285):586-9. doi: 10.1126/science.aad8852.