Division of Respiratory Medicine, Mito Medical Center, Ibaraki-machi, Japan.
Division of Respiratory Medicine, Hitachi General Hospital, Hitachi, Japan.
In Vivo. 2020 Jul-Aug;34(4):2095-2100. doi: 10.21873/invivo.12013.
To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients.
CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml.
In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis.
Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options.
明确血清癌胚抗原（CEA）和细胞角蛋白 19 片段（CYFRA）水平与间变性淋巴瘤激酶（ALK）重排非小细胞肺癌（NSCLC）患者转移和生存的相关性。
采用荧光原位杂交（FISH）、实时逆转录聚合酶链反应和免疫组织化学法，使用活检标本、细胞学标本和血浆标本检测 131 例 ALK 重排 NSCLC 患者的 CEA 和 CYFRA 水平。每个标志物的截断值均确定为 10ng/ml。
在逻辑回归分析中，两种标志物水平升高均与骨转移呈正相关，CYFRA 水平升高与肝转移和多器官转移相关。然而，在 Cox 比例模型分析中，这些标志物并未被证明是预后不良的因素。
血清 CEA 和 CYFRA 水平升高似乎提供了有关骨和肝转移以及多器官转移存在的有用临床信息，尽管它们不是预后的有力指标。这两个标志物可能提示转移的范围，有助于考虑治疗方案。
