Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
In Vivo. 2020 Jul-Aug;34(4):2173-2177. doi: 10.21873/invivo.12026.
BACKGROUND/AIM: Radical hysterectomy has been used for local recurrent or persistent (LR) cervical cancer after radiotherapy (RT), but the rate of serious complications is high and tolerance is low. This study determined the efficacy, safety, and prognostic factors of adjuvant simple hysterectomy in LR cervical cancer post-RT.
A total of 21 patients who underwent hysterectomy for LR cervical cancer post-RT in our Department between May 2007 and September 2018 were included in the study. Primary, definitive RT was performed. Histological response by definitive RT in the extirpated uterus was classified on the basis of histological response criteria: effect (Ef) 0-3.
The 5-year overall survival (OS) and disease-free survival (DFS) rates were 51.9% and 50.1%, respectively. Ef 1 was significantly associated with poorer prognosis compared to Ef 2 or Ef 3.
Adjuvant hysterectomy could be a treatment of choice for LR cervical cancer post-RT.
背景/目的：根治性子宫切除术已被用于放疗（RT）后局部复发或持续性（LR）宫颈癌，但严重并发症发生率高，耐受性低。本研究旨在确定 LR 宫颈癌根治性放疗后辅助单纯子宫切除术的疗效、安全性和预后因素。
本研究纳入了 2007 年 5 月至 2018 年 9 月我科因 LR 宫颈癌接受子宫切除术的 21 例患者。行原发性、根治性 RT。根据切除子宫的组织学反应标准，将根治性 RT 的组织学反应分为：有效（Ef）0-3。
5 年总生存率（OS）和无病生存率（DFS）分别为 51.9%和 50.1%。Ef 1 与 Ef 2 或 Ef 3 相比，预后明显较差。
辅助性子宫切除术可能是 LR 宫颈癌根治性放疗后的一种治疗选择。
