C5a在体外刺激人单核细胞分泌肿瘤坏死因子。与白细胞介素1β和白细胞介素1α分泌的比较。
C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.
作者信息
Okusawa S, Yancey K B, van der Meer J W, Endres S, Lonnemann G, Hefter K, Frank M M, Burke J F, Dinarello C A, Gelfand J A
机构信息
Department of Medicine, Tufts University, Boston, Massachusetts 02111.
出版信息
J Exp Med. 1988 Jul 1;168(1):443-8. doi: 10.1084/jem.168.1.443.
Abstract
We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-alpha, IL-1 beta, and IL-1 alpha, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-alpha and IL-1 beta secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1 alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.
摘要
我们已经证明，纯化的C5a是刺激人外周血单核细胞分泌肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-1α（IL-1α）的有效刺激物，且这种刺激呈剂量依赖性。在给定的C5a浓度下，TNF-α和IL-1β的分泌没有显著差异；两者的分泌量均明显高于IL-1α。诸如革兰氏阳性和革兰氏阴性细菌感染、创伤及免疫复合物疾病等临床病症会激活补体。通过C5a诱导分泌的TNF和IL-1的介导作用，这些不同的病症可能具有发热、凝血病、急性期蛋白产生及代谢紊乱等共同特征。
相似文献
1
C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.C5a在体外刺激人单核细胞分泌肿瘤坏死因子。与白细胞介素1β和白细胞介素1α分泌的比较。
J Exp Med. 1988 Jul 1;168(1):443-8. doi: 10.1084/jem.168.1.443.
2
C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.人白细胞介素1的C5a诱导。与内毒素或γ干扰素的协同效应。
J Immunol. 1987 Oct 15;139(8):2635-40.
3
Polymyxin-B stimulates tumor necrosis factor-alpha production by human peripheral blood mononuclear cells.
Int J Artif Organs. 1998 May;21(5):269-73.
4
5
Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells.人单核细胞白细胞介素1α、白细胞介素1β和肿瘤坏死因子合成及释放动力学的差异
Eur J Immunol. 1989 Sep;19(9):1531-6. doi: 10.1002/eji.1830190903.
6
The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1.C5a在脂多糖或白细胞介素-1诱导的白细胞介素-6产生中的作用。
Immunology. 1991 Nov;74(3):373-9.
7
8
Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by alpha-melanocyte-stimulating hormone.
J Immunol. 1989 Mar 1;142(5):1646-51.
9
The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway.C5a对单核细胞的启动作用主要由p38丝裂原活化蛋白激酶（MAPK）途径介导。
Shock. 2007 Jun;27(6):623-30. doi: 10.1097/SHK.0b013e31802fa0bd.
10
Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A.脂多糖A合成前体Ia对脂多糖诱导的肿瘤坏死因子、白细胞介素1和白细胞介素6产生的调节作用
FEMS Microbiol Immunol. 1992 Jan;4(2):73-89. doi: 10.1111/j.1574-6968.1992.tb04973.x.
引用本文的文献
1
Thrombosis in Paroxysmal Nocturnal Hemoglobinuria (PNH): From Pathogenesis to Treatment.阵发性睡眠性血红蛋白尿症（PNH）中的血栓形成：从发病机制到治疗。
Int J Mol Sci. 2024 Nov 11;25(22):12104. doi: 10.3390/ijms252212104.
2
Interactions between Mycoplasma mycoides subsp. mycoides and bovine macrophages under physiological conditions.牛支原体亚种与牛巨噬细胞在生理条件下的相互作用。
PLoS One. 2024 Jun 27;19(6):e0305851. doi: 10.1371/journal.pone.0305851. eCollection 2024.
3
Elevated Complement Activation Fragments and C1q-Binding Circulating Immune Complexes in Varied Phases of Chikungunya Virus Infection.在基孔肯雅病毒感染的不同阶段，补体激活片段和 C1q 结合的循环免疫复合物升高。
Curr Microbiol. 2024 Jun 24;81(8):242. doi: 10.1007/s00284-024-03732-7.
4
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation.干细胞衍生的脑干小鼠星形胶质细胞在神经炎症时会在体外获得神经毒性表型。
J Inflamm (Lond). 2023 Jun 27;20(1):22. doi: 10.1186/s12950-023-00349-8.
5
Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury.创伤性脑损伤后的神经炎症治疗：补体抑制作为二次损伤的治疗方法。
Neurotherapeutics. 2023 Jan;20(1):284-303. doi: 10.1007/s13311-022-01306-8. Epub 2022 Oct 12.
6
Systematic review of atypical hemolytic uremic syndrome biomarkers.非典型溶血尿毒综合征生物标志物的系统评价
Pediatr Nephrol. 2022 Jul;37(7):1479-1493. doi: 10.1007/s00467-022-05451-2. Epub 2022 Feb 3.
7
In Vivo Pharmacodynamic Method to Assess Complement C5a Receptor Antagonist Efficacy.评估补体C5a受体拮抗剂疗效的体内药效学方法。
ACS Pharmacol Transl Sci. 2021 Dec 21;5(1):41-51. doi: 10.1021/acsptsci.1c00227. eCollection 2022 Jan 14.
8
C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease.C5基因变体rs10985126与有症状冠状动脉疾病患者的死亡率相关。
Pharmgenomics Pers Med. 2021 Jul 21;14:893-903. doi: 10.2147/PGPM.S307827. eCollection 2021.
9
Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5a.补体调控在人类腱细胞受过敏毒素 C5a 影响下的作用。
Int J Mol Sci. 2021 Mar 18;22(6):3105. doi: 10.3390/ijms22063105.
10
Binding of raloxifene to human complement fragment 5a (C5a): a perspective on cytokine storm and COVID19.雷洛昔芬与人补体片段 5a（C5a）的结合：细胞因子风暴与 COVID19 的新视角。
J Biomol Struct Dyn. 2022 Feb;40(3):982-994. doi: 10.1080/07391102.2020.1820381. Epub 2020 Sep 15.
本文引用的文献
1
Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors.人C5a与巨噬细胞表面C5a受体结合诱导白细胞介素1分泌并增强体液免疫。
J Exp Med. 1982 Sep 1;156(3):912-7. doi: 10.1084/jem.156.3.912.
2
The detection of endotoxin by in vitro production of endogenous pyrogen: comparison with limulus amebocyte lysate gelation.通过内源性致热原的体外产生检测内毒素：与鲎试剂凝胶化法的比较。
J Immunol Methods. 1982 Aug 13;52(3):323-31. doi: 10.1016/0022-1759(82)90004-7.
3
4
Biologically active products of complement and acute lung injury in patients with the sepsis syndrome.脓毒症综合征患者补体的生物活性产物与急性肺损伤
Am Rev Respir Dis. 1984 Nov;130(5):791-6. doi: 10.1164/arrd.1984.130.5.791.
5
Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation.由N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸或补体成分C5a刺激的人多形核白细胞的花生四烯酸代谢与磷脂酶激活无关。
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7200-4. doi: 10.1073/pnas.80.23.7200.
6
Human C5a des Arg increases vascular permeability.人C5a去精氨酸产物可增加血管通透性。
J Immunol. 1981 Dec;127(6):2376-80.
7
Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value.补体激活及血浆C5a升高与成人呼吸窘迫综合征的关联。病理生理相关性及可能的预后价值。
Lancet. 1980 May 3;1(8175):947-9. doi: 10.1016/s0140-6736(80)91403-8.
8
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.针对恶病质素/肿瘤坏死因子的被动免疫可保护小鼠免受内毒素的致死作用。
Science. 1985 Aug 30;229(4716):869-71. doi: 10.1126/science.3895437.
9
Shock and tissue injury induced by recombinant human cachectin.重组人恶病质素诱导的休克和组织损伤
Science. 1986 Oct 24;234(4775):470-4. doi: 10.1126/science.3764421.
10
Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.恶病质素（肿瘤坏死因子）合成的调控：内毒素耐受机制
Science. 1986 May 23;232(4753):977-80. doi: 10.1126/science.3754653.
Zotero 插件