Orofacial Pain & TMD Research Unit, Institute of Stomatology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, People's Republic of China.
Department of Periodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Clin Oral Investig. 2021 Mar;25(3):1223-1233. doi: 10.1007/s00784-020-03427-w. Epub 2020 Jul 2.
The purpose of this preliminary study was to explore blood microcirculation and somatosensory profiles in periodontitis patients before and after non-surgical periodontal therapy.
Twenty patients (10 men and 10 women, 20 to 30 years old) and 20 age- and gender-matched healthy controls were included. Non-surgical periodontal therapy was performed for all patients. Clinical examination including pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) were performed at baseline (BL), 1 week (1W), and 4 weeks (4W) after non-surgical periodontal therapy on 6 sites of tooth 32 and 42. Laser Doppler flowmetry (LDF) and quantitative sensory testing (QST) were applied at the attached gingiva of tooth 32 and 42 at BL, 1W, and 4W after non-surgical periodontal therapy. Data were analyzed with a two-way mixed-model of ANOVA.
The PPD, CAL and BOP significantly improved after non-surgical periodontal therapy (p < 0.001). Periodontitis patients demonstrated a higher tissue microvascular blood cell concentration (p = 0.015) and a significant gain in thermal (p = 0.037) and mechanical (p = 0.003) somatosensory function compared to controls. After non-surgical periodontal therapy, the flux (p = 0.002) and speed (p = 0.008) of blood flow decreased significantly and thermal (p = 0.029) and mechanical (p < 0.001) somatosensory function were reversed.
Gingival microcirculation and somatosensory function seem impaired in patients with periodontitis and are reversed following non-surgical periodontal therapy.
LDF and QST may be appropriate tools to further characterize gingival inflammation and treatment responses in periodontitis.
本初步研究旨在探讨牙周炎患者在非手术牙周治疗前后的血液微循环和体感特征。
共纳入 20 名患者（10 男 10 女，年龄 20-30 岁）和 20 名年龄和性别匹配的健康对照者。所有患者均接受非手术牙周治疗。在非手术牙周治疗前（BL）、治疗后 1 周（1W）和 4 周（4W），对牙 32 和 42 的 6 个位点进行临床检查，包括探诊深度（PPD）、临床附着丧失（CAL）和探诊出血（BOP）。在 BL、非手术牙周治疗后 1W 和 4W，应用激光多普勒血流仪（LDF）和定量感觉测试（QST）检测牙 32 和 42 的附着龈。采用双向混合模型方差分析对数据进行分析。
非手术牙周治疗后 PPD、CAL 和 BOP 显著改善（p<0.001）。与对照组相比，牙周炎患者组织微血管血细胞浓度较高（p=0.015），热觉（p=0.037）和机械觉（p=0.003）体感功能显著提高。非手术牙周治疗后，血流通量（p=0.002）和速度（p=0.008）明显下降，热觉（p=0.029）和机械觉（p<0.001）体感功能逆转。
牙周炎患者的牙龈微循环和体感功能似乎受损，经非手术牙周治疗后得到逆转。
LDF 和 QST 可能是进一步描述牙周炎牙龈炎症和治疗反应的合适工具。
