Student Research Committee, Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Phytother Res. 2020 Dec;34(12):3137-3147. doi: 10.1002/ptr.6781. Epub 2020 Jul 2.
At the end of 2019, a novel flu-like coronavirus named COVID-19 (coronavirus disease 2019) was recognized by World Health Organization. No specific treatments exist for COVID-19 at this time. New evidence suggests that therapeutic options focusing on antiviral agents may alleviate COVID-19 symptoms as well as those that lead to the decrease in the inflammatory responses. Flavonoids, as phenolic compounds, have attracted considerable attention due to their various biological properties. In this review, the promising effects and possible mechanisms of action of naringenin, a citrus-derived flavonoid, against COVID-19 were discussed. We searched PubMed/Medline, Science direct, Scopus, and Google Scholar databases up to March 2020 using the definitive keywords. The evidence reviewed here indicates that naringenin might exert therapeutic effects against COVID-19 through the inhibition of COVID-19 main protease, 3-chymotrypsin-like protease (3CLpro), and reduction of angiotensin converting enzyme receptors activity. One of the other mechanisms by which naringenin might exert therapeutic effects against COVID-19 is, at least partly, by attenuating inflammatory responses. The antiviral activity of the flavanone naringenin against some viruses has also been reported. On the whole, the favorable effects of naringenin lead to a conclusion that naringenin may be a promising treatment strategy against COVID-19.
2019 年末，世界卫生组织（WHO）确认了一种新型的流感样冠状病毒，名为 COVID-19（2019 年冠状病毒病）。目前，尚无针对 COVID-19 的特定治疗方法。新的证据表明，专注于抗病毒药物的治疗选择可能会缓解 COVID-19 症状以及导致炎症反应下降的症状。类黄酮作为酚类化合物，由于其多种生物学特性而受到广泛关注。在这篇综述中，讨论了源自柑橘的类黄酮柚皮素针对 COVID-19 的有希望的作用和可能的作用机制。我们使用明确的关键词，在 2020 年 3 月之前，在 PubMed/Medline、Science direct、Scopus 和 Google Scholar 数据库中进行了搜索。这里综述的证据表明，柚皮素可能通过抑制 COVID-19 主要蛋白酶（3CLpro）和降低血管紧张素转换酶受体活性，对 COVID-19 发挥治疗作用。柚皮素对 COVID-19 发挥治疗作用的另一种机制是，至少部分通过减轻炎症反应。也有报道称，该黄酮类化合物柚皮素对某些病毒具有抗病毒活性。总的来说，柚皮素的有利影响得出的结论是，柚皮素可能是针对 COVID-19 的一种有前途的治疗策略。
