Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.
Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Front Immunol. 2020 Sep 25;11:570919. doi: 10.3389/fimmu.2020.570919. eCollection 2020.
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection.
2019 年冠状病毒病（COVID-19）是由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的，世界卫生组织于 2020 年 3 月宣布其为大流行病。严重 COVID-19 病例会发展为严重急性呼吸系统综合症，这可能导致多器官衰竭、败血症和死亡。高风险人群包括老年人和患有肥胖症、高血压和糖尿病等慢性病的人群。迄今为止，尚无针对 COVID-19 的特定治疗方法或疫苗。在许多化合物中，柚皮素（NAR）是一种存在于柑橘类水果中的类黄酮，已被研究具有抗病毒和抗炎特性，如减少病毒复制和细胞因子产生。从这个角度来看，我们总结了 NAR 在 COVID-19 相关风险因素和 SARS-CoV-2 感染中的潜在抗炎作用。
