油酰乙醇酰胺，一种生物活性脂质酰胺，作为一种有前途的冠状病毒/COVID-19 治疗策略。
Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19.
机构信息
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Arch Med Res. 2020 Jul;51(5):464-467. doi: 10.1016/j.arcmed.2020.04.006. Epub 2020 Apr 15.
Abstract
The current outbreak of COVID-19 (coronavirus) has been identified by World Health Organization (WHO) as a global pandemic. With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. Bioactive lipids with an array of known health-promoting properties can be suggested as effective agents in alleviating acute respiratory stress induced by virus. The bioactive lipid amide, oleoylethanolamide (OEA), due to several distinctive homeostatic properties, including anti-inflammatory activities, modulation of immune response, and anti-oxidant effects can be considered as a novel potential pharmacological alternative for the management of COVID-19.
摘要
目前由世界卫生组织（WHO）确定的 COVID-19（冠状病毒）爆发为全球大流行。随着 COVID-19 病毒的出现，并且考虑到缺乏针对它的有效药物治疗，因此迫切需要在这方面确定安全有效的药物或潜在的辅助疗法。具有多种已知促进健康特性的生物活性脂质可被认为是缓解病毒引起的急性呼吸应激的有效药物。生物活性脂质酰胺，油酰乙醇酰胺（OEA），由于其具有几种独特的体内平衡特性，包括抗炎活性、调节免疫反应和抗氧化作用，因此可以被认为是管理 COVID-19 的一种新型潜在的药理学替代药物。
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