Parviz Dorsa, Bitounis Dimitrios, Demokritou Philip, Strano Michael
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue 66-570b Cambridge, MA 02139, USA.
Center for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T. H. Chan School of Public School, Harvard University, 665 Huntington, Boston, MA 02115, USA.
NanoImpact. 2020 Apr;18. doi: 10.1016/j.impact.2020.100226. Epub 2020 Apr 18.
Emerging, two-dimensional engineered nanomaterials (2DNMs) possess unique and diverse physical and chemical properties, such as extreme aspect ratios, adjustable electronic properties as well as functional lattice defects and surface chemistry which underpin their interactions with biological systems. This perspective highlights the need for structure activity relationship (SAR) studies for key properties of emerging grapheme-related and inorganic 2DNMs upon prioritization based on their potential impact and trajectory for large-scale production and applications. Further, it is discussed how a synthesis platform of microbiologically sterile, size-sorted, "model" 2DNMs with precise structure would enable SAR toxicological studies and allow for the sustainable and safe translation of 2D nanotechnology to real-world applications.
新兴的二维工程纳米材料（2DNMs）具有独特多样的物理和化学性质，如极高的纵横比、可调节的电子性质以及功能性晶格缺陷和表面化学性质，这些性质支撑着它们与生物系统的相互作用。本文观点强调，鉴于新兴的石墨烯相关和无机2DNMs的关键性质对大规模生产和应用的潜在影响及发展轨迹，有必要对其进行构效关系（SAR）研究。此外，还讨论了一个具有精确结构的微生物无菌、尺寸分选的“模型”2DNMs合成平台如何能够开展SAR毒理学研究，并实现二维纳米技术向实际应用的可持续和安全转化。
