Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University , Chengdu, China.
Global Health Drug Discovery Institute , Beijing, China.
Expert Opin Drug Deliv. 2020 Sep;17(9):1289-1304. doi: 10.1080/17425247.2020.1788541. Epub 2020 Aug 4.
Drug delivery systems with extended-release profiles are ideal in improving patient compliance with enhanced efficacy. To develop devices capable of a prolonged delivery kinetics, it is crucial to understand the various underlying mechanisms contributing to extended drug release and the impact thereof on modulating the long-term performance of such systems in a practical application environment.
This review article intends to provide a comprehensive summary of release mechanisms in extended-release drug delivery systems, particularly polymer-based systems; however, other material types will also be mentioned. Selected current research in the delivery of small molecule drugs and macromolecules is highlighted. Emphasis is placed on the combined impact of different release mechanisms and drug properties on the long-term release kinetics and .
The development of drug delivery systems over an extended duration is promising but also challenging when considering the numerous interrelated delivery-related parameters. Achieving a well-controlled extended drug release requires advanced techniques to minimize burst release and lag phase, a better understanding of the dynamic interrelationship between drug properties and release profiles over time, and a thorough elucidation of the impact of multiple conditions to methodically evaluate the eventual clinical efficacy.
具有缓释特征的药物输送系统可提高患者的顺应性并增强疗效。为了开发能够实现长时间药物输送动力学的设备，了解导致药物延长释放的各种潜在机制及其对调节此类系统在实际应用环境中的长期性能的影响至关重要。
本文旨在全面总结延长释放药物输送系统（特别是基于聚合物的系统）的释放机制；然而，也会提到其他材料类型。突出强调了小分子药物和大分子药物输送方面的当前研究进展。重点关注不同释放机制和药物特性对长期释放动力学的综合影响。
在考虑到众多相互关联的输送相关参数的情况下，开发延长时间的药物输送系统具有广阔的前景，但也极具挑战性。要实现良好控制的延长药物释放，需要先进的技术来最小化突释和滞后期，更好地理解药物特性与随时间推移的释放曲线之间的动态相互关系，并彻底阐明多种条件的影响，以系统地评估最终的临床疗效。
