Aghabegi Moghanjoughi Arezou, Khoshnevis Dorna, Zarrabi Ali
Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.
Department of Renewable Energy Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.
Drug Deliv Transl Res. 2016 Jun;6(3):333-40. doi: 10.1007/s13346-015-0274-7.
Design and synthesis of efficient drug delivery systems are of critical importance in health care management. Innovations in materials chemistry especially in polymer field allows introduction of advanced drug delivery systems since polymers could provide controlled release of drugs in predetermined doses over long periods, cyclic and tunable dosages. To this end, researchers have taken advantages of smart polymers since they can undergo large reversible, chemical, or physical fluctuations as responses to small changes in environmental conditions, for instance, in pH, temperature, light, and phase transition. The present review aims to highlight various kinds of smart polymers, which are used in controlled drug delivery systems as well as mechanisms of action and their applications.
高效药物递送系统的设计与合成在医疗保健管理中至关重要。材料化学的创新，尤其是聚合物领域的创新，使得先进的药物递送系统得以引入，因为聚合物能够长时间以预定剂量、循环且可调节的剂量实现药物的控释。为此，研究人员利用了智能聚合物，因为它们能够随着环境条件的微小变化，如pH值、温度、光照和相变等，发生大幅度的可逆化学或物理变化。本综述旨在重点介绍用于控释药物递送系统的各类智能聚合物及其作用机制和应用。
