Institute of Rheumatology, Resavska 69, Belgrade, 11000, Serbia.
University of Belgrade Medical School, Institute of Rheumatology, Belgrade, Serbia.
BMC Oral Health. 2020 Jul 3;20(1):187. doi: 10.1186/s12903-020-01169-5.
The aim of this study was to evaluate chemosensory function and oral disorders in patients with primary Sjögren's syndrome (pSS) and to compare these findings with those of age- and gender-matched healthy controls.
This comparative cross-sectional study included 58 patients with primary Sjögren's syndrome (pSS) and 55 age- and gender-matched healthy controls. Olfactory and gustatory function, burning sensations in the tongue (BST) and halitosis were assessed. Oral health-related quality of life (OHRQoL) was evaluated using the short-form Oral Health Impact Profile (OHIP-14).
Patients with pSS had significantly lower self-reported visual analogue scale (VAS) smell score (8.6 ± 2.2 vs. 9.6 ± 0.7, p = 0.016) and VAS taste score (8.5 ± 2.1 vs. 9.5 ± 0.7, p = 0.014) than healthy controls. A greater proportion of patients with pSS had anosmia (3.8% vs. 0.0%) or hyposmia (36.5% vs. 13.2%) and ageusia for basic tastes: sweetness (34.0% vs. 7.5%), sourness (10.6% vs. 0.0), saltiness (10.0% vs. 5.7%) or bitterness (19.1% vs. 1.9%) as evaluated using Sniffin Sticks test and taste stripts, respectively. A higher proportion of pSS patients complained of dysgeusia (52.6% vs. 9.4%, p < 0.0001) and BST (45.6% vs. 0.0%, p < 0.0001), while similar number of patients with pSS and controls reported halitosis (31.6% vs. 28.3%, p = 0.434). The mean OHIP-14 score was significantly higher in patients with pSS (6.8 ± 7.0 vs. 2.3 ± 8.5, p < 0.001) indicating patients' poorer OHRQoL compared with controls.
The majority of patients with pSS had impaired chemosensory function and indicators of oral health in comparison with the age- and gender-matched healthy controls. Further studies of oral hygiene habits and dietary intake of these patients are needed to ensure better management of oral health problems in patients with pSS.
本研究旨在评估原发性干燥综合征（pSS）患者的化学感觉功能和口腔疾病，并将这些发现与年龄和性别匹配的健康对照组进行比较。
这是一项比较性横断面研究，纳入了 58 例原发性干燥综合征（pSS）患者和 55 名年龄和性别匹配的健康对照组。评估了嗅觉和味觉功能、舌烧灼感（BST）和口臭。使用简化口腔健康影响量表（OHIP-14）评估口腔健康相关生活质量（OHRQoL）。
与健康对照组相比，pSS 患者的自我报告视觉模拟量表（VAS）嗅觉评分（8.6±2.2 对 9.6±0.7，p=0.016）和 VAS 味觉评分（8.5±2.1 对 9.5±0.7，p=0.014）明显较低。pSS 患者中嗅觉丧失（3.8%对 0.0%）或嗅觉减退（36.5%对 13.2%）和基本味觉味觉减退的比例更高：甜味（34.0%对 7.5%）、酸味（10.6%对 0.0%）、咸味（10.0%对 5.7%）或苦味（19.1%对 1.9%），分别通过 Sniffin Sticks 测试和味觉条进行评估。pSS 患者味觉障碍（52.6%对 9.4%，p<0.0001）和 BST（45.6%对 0.0%，p<0.0001）的抱怨比例更高，而 pSS 患者和对照组报告口臭的患者比例相似（31.6%对 28.3%，p=0.434）。pSS 患者的平均 OHIP-14 评分明显更高（6.8±7.0 对 2.3±8.5，p<0.001），表明与对照组相比，pSS 患者的口腔健康相关生活质量更差。需要进一步研究这些患者的口腔卫生习惯和饮食摄入，以确保更好地管理 pSS 患者的口腔健康问题。
