Gheisari Mehdi, Zerehpoosh Farahnaz Bidari, Zaresharifi Shirin
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran.
Dermatol Online J. 2020 May 15;26(5):13030/qt5871q750.
Pyodermatitis-pyostomatitis vegetans is a rare inflammatory dermatosis. There is a strong association between pyodermatitis-pyostomatitis vegetans and inflammatory bowel disease, particularly ulcerative colitis. Herein, we report a case of pyodermatitis-pyostomatitis vegetans with positive direct immunofluorescence staining findings and review the literature for the past 18 years to characterize the disease, its epidemiologic characteristics, its associations, and the pathology and direct and indirect immunofluorescence findings. The total number of cases was 38, including 22 men and 16 women, with an average age of forty. Direct immunofluorescence staining had been performed for 32 patients, of which 12 had positive findings. Of those with positive direct immunofluorescence, 6 patients showed IgA cell surface staining. A recent approach suggests that these immunological findings may not be accidental and indicates a possible overlap with autoimmune bullous diseases discussed in this review.
增殖性脓皮病-增殖性口炎是一种罕见的炎症性皮肤病。增殖性脓皮病-增殖性口炎与炎症性肠病，尤其是溃疡性结肠炎之间存在密切关联。在此，我们报告一例增殖性脓皮病-增殖性口炎患者，其直接免疫荧光染色结果呈阳性，并回顾过去18年的文献，以描述该疾病的特征、流行病学特征、关联因素以及病理学和直接及间接免疫荧光检查结果。病例总数为38例，其中男性22例，女性16例，平均年龄为40岁。对32例患者进行了直接免疫荧光染色，其中12例结果呈阳性。在直接免疫荧光阳性的患者中，6例显示IgA细胞表面染色。最近的一种观点认为，这些免疫检查结果可能并非偶然，提示可能与本文所讨论的自身免疫性大疱性疾病存在重叠。
