Bjørklund Geir, Pivina Lyudmila, Dadar Maryam, Meguid Nagwa A, Semenova Yuliya, Anwar Mona, Chirumbolo Salvatore
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway; CONEM Scientific Secretary, Verona, Italy.
Semey Medical University, Semey, Kazakhstan; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan; CONEM Scientific Secretary, Verona, Italy.
Neurosci Biobehav Rev. 2020 Nov;118:111-120. doi: 10.1016/j.neubiorev.2020.06.033. Epub 2020 Jul 1.
There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increased intestinal permeability. Moreover, in many studies, large differences in the composition of intestinal microbiota and metabolic products between ASD patients and controls were reported. Deepening the role and the biology of the gut microbiome may be fundamental to elucidate the onset of GI symptoms in ASD individuals and their etiopathogenetic causes. The gut-brain axis may affect brain development and behaviors through the neuroendocrine, neuroimmune, and autonomic nervous systems.
越来越多的证据表明，患有自闭症谱系障碍（ASD）的儿童与胃肠道（GI）症状有关，如腹痛、慢性腹泻、便秘、呕吐、胃食管反流、肠道感染和肠道通透性增加。此外，在许多研究中，报告了ASD患者与对照组之间肠道微生物群和代谢产物组成的巨大差异。深入了解肠道微生物群的作用和生物学特性可能是阐明ASD个体胃肠道症状的发作及其病因的基础。肠-脑轴可能通过神经内分泌、神经免疫和自主神经系统影响大脑发育和行为。
