Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong.
Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong.
Acta Biomater. 2020 Sep 1;113:101-118. doi: 10.1016/j.actbio.2020.06.039. Epub 2020 Jul 1.
Although contact lenses are widely used for vision correction, they are also the primary cause of a number of ocular diseases such as microbial keratitis (MK), etc. and inflammatory events such as infiltrative keratitis (IK), contact lens acute red eye (CLARE), contact lens-induced peripheral ulcer (CLPU), etc. These diseases and infiltrative events often result from microbial contamination of lens care solutions and lens cases that can be exacerbated by unsanitary lens care and extended lens wear. The treatment of microbial biofilms (MBs) on lens cases and contact lenses are complicated and challenging due to their resistance to conventional antimicrobial lens care solutions. More importantly, MK caused by MBs can lead to acute visual damage or even vision impairment. Therefore, the development of lens cases, lens care solutions, and contact lenses with effective antimicrobial performance against MK will contribute to the safe use of contact lenses. This review article summarizes and discusses different chemical approaches for the development of antimicrobial contact lenses and lens cases employing passive surface modifications, antimicrobial peptides, free-radical fabricating agents, quorum sensing quenchers, antibiotics, antifungal drugs and various metals and coatings with antimicrobial nanomaterials. The benefits and shortcomings of these approaches are assessed, and alternative solutions for future developments are discussed.
虽然隐形眼镜被广泛用于视力矫正，但它们也是许多眼部疾病的主要原因，如微生物角膜炎（MK）等，以及炎症事件，如浸润性角膜炎（IK）、隐形眼镜急性红眼（CLARE）、隐形眼镜诱导的周边溃疡（CLPU）等。这些疾病和炎症事件通常是由于隐形眼镜护理液和镜盒中的微生物污染引起的，不卫生的隐形眼镜护理和延长佩戴时间会加剧这种情况。由于常规的抗菌隐形眼镜护理液对微生物生物膜（MBs）的抵抗力，对镜盒和隐形眼镜上的 MBs 的治疗变得复杂和具有挑战性。更重要的是，MBs 引起的 MK 可导致急性视力损害，甚至视力障碍。因此，开发具有有效抗 MK 性能的隐形眼镜和镜盒，对于安全使用隐形眼镜至关重要。本文综述和讨论了不同的化学方法，用于开发具有抗菌性能的隐形眼镜和镜盒，包括被动表面改性、抗菌肽、自由基制造剂、群体感应抑制剂、抗生素、抗真菌药物以及具有抗菌纳米材料的各种金属和涂层。评估了这些方法的优缺点，并讨论了未来发展的替代解决方案。
