Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.
CSIR-Advanced Materials and Processes Research Institute, Hoshangabad Road, Bhopal 462026, India.
ACS Biomater Sci Eng. 2020 May 11;6(5):3162-3173. doi: 10.1021/acsbiomaterials.0c00229. Epub 2020 Apr 9.
Contact lens is a major risk factor for microbial keratitis among contact lens wearers. Chemical strategies that can prevent microbial adhesion and biofilm formation are required to improve a wearer's hygiene and safety. Taking advantage of the material-independent properties of a polydopamine (pDA) coating, we investigated the role of covalent/noncovalent interactions of the antimicrobials and pDA in conferring long-term antimicrobial activities. The developed antimicrobial contact lenses not only retain their antibacterial efficiency against different bacterial strains for 2 weeks but also inhibit microbial adhesion and biofilm formation on the lens surfaces. The designed antimicrobial coatings were found to be safe for ocular cell lines. Moreover, the antimicrobial coatings did not affect the functional and surface properties of coated contact lenses. This methodology can be used to protect the contact lenses from microbial contamination for prolonged periods and has the potential to be extended for designing antimicrobial coatings for other medical devices as well.
隐形眼镜是隐形眼镜佩戴者微生物角膜炎的一个主要危险因素。需要采取化学策略来防止微生物黏附和生物膜形成，以提高佩戴者的卫生和安全性。我们利用聚多巴胺（pDA）涂层的材料独立特性，研究了抗菌剂与 pDA 的共价/非共价相互作用在赋予长期抗菌活性方面的作用。所开发的抗菌隐形眼镜不仅保留了其对不同细菌菌株长达 2 周的抗菌效率，而且还抑制了镜片表面上微生物的黏附和生物膜形成。所设计的抗菌涂层对眼细胞系是安全的。此外，抗菌涂层不会影响涂层隐形眼镜的功能和表面特性。该方法可用于延长隐形眼镜免受微生物污染的时间，并且有可能扩展到其他医疗器械的抗菌涂层设计。
