UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK; Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R + D Pharma Group (GI-1645), Universidade de Santiago de Compostela, 15782, Spain.
Int J Pharm. 2020 Aug 30;586:119594. doi: 10.1016/j.ijpharm.2020.119594. Epub 2020 Jul 2.
Pharmaceutical three-dimensional (3D) printing is a modern fabrication process with the potential to create bespoke drug products of virtually any shape and size from a computer-aided design model. Selective laser sintering (SLS) 3D printing combines the benefits of high printing precision and capability, enabling the manufacture of medicines with unique engineering and functional properties. This article reviews the current state-of-the-art in SLS 3D printing, including the main principles underpinning this technology, and highlights the diverse selection of materials and essential parameters that influence printing. The technical challenges and processing conditions are also considered in the context of their effects on the printed product. Finally, the pharmaceutical applications of SLS 3D printing are covered, providing an emphasis on the advantages the technology offers to drug product manufacturing and personalised medicine.
药物三维（3D）打印是一种现代制造工艺，具有从计算机辅助设计模型中创建任何形状和大小的定制药物产品的潜力。选择性激光烧结（SLS）3D 打印结合了高精度和高能力的优点，能够制造具有独特工程和功能特性的药物。本文综述了 SLS 3D 打印的最新技术，包括该技术的主要原理，并重点介绍了影响打印的多种材料和基本参数。还考虑了技术挑战和加工条件对打印产品的影响。最后，涵盖了 SLS 3D 打印在制药方面的应用，重点介绍了该技术在药物产品制造和个性化医疗方面的优势。
