Section for Genetics and Evolutionary Biology, Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
Institute for Developmental Genetics and Cluster of Excellence on Plant Sciences, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Curr Opin Plant Biol. 2020 Oct;57:41-51. doi: 10.1016/j.pbi.2020.05.010. Epub 2020 Jul 2.
Organisms need to constantly inform their cellular machinery about the biochemical and physical status of their surroundings to adapt and thrive. While some external signals are also sensed intracellularly, a considerable share of external information is registered already at the plasma membrane (PM). Receptor kinases (RKs) are crucial for plant cells to integrate such cues from the environment, from microbes, or from other cells to coordinate their physiological response and their development. Early studies on RK signaling depicted the path from external signal to internal response in a linear fashion, but recent findings show that these cellular information highways are highly interconnected and pass signals through molecular intersections. In this review, we first discuss how individual RKs simultaneously contribute to the transduction and deconvolution of a multitude of signals by controlled assembly into diverse RK complexes, exemplified by FERONIA signaling versatility. We then elaborate on how cells can exert highly localized control over the assembly, interaction and composition of such complexes in order to attain essential cellular output specificity.
生物体需要不断向其细胞机器告知其周围环境的生化和物理状态，以适应和茁壮成长。虽然一些外部信号也在细胞内被感知，但相当一部分外部信息已经在质膜 (PM) 上被记录下来。受体激酶 (RKs) 对于植物细胞整合来自环境、微生物或其他细胞的这些线索以协调其生理反应和发育至关重要。早期的 RK 信号研究以线性方式描述了从外部信号到内部反应的路径，但最近的发现表明，这些细胞信息高速公路高度互联，并通过分子交叉点传递信号。在这篇综述中，我们首先讨论了单个 RK 如何通过受控组装成多种 RK 复合物，同时为众多信号的转导和解码做出贡献，以 FERONIA 信号的多功能性为例。然后，我们详细阐述了细胞如何对这些复合物的组装、相互作用和组成进行高度局部控制，以实现必要的细胞输出特异性。
