Bampidis Vasileios, de Lourdes Bastos Maria, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Costa Lucio, Dierick Noël, Flachowsky Gerhard, Glandorf Boet, Herman Lieve, Leng Lubomir, Mantovani Alberto, Saarela Maria, Wallace Robert John, Anguita Montserrat, Tarrés-Call Jordi, Ramos Fernando
EFSA J. 2019 May 7;17(5):e05694. doi: 10.2903/j.efsa.2019.5694. eCollection 2019 May.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-tryptophan produced by fermentation using KCCM 80135 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain and its recombinant DNA were not detected in the additive. l-Tryptophan produced by fermentation with KCCM 80135 does not raise any safety concern with regard to the genetic modification of the production strain. The use of l-tryptophan produced using KCCM 80135 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non-ruminant target species. Using unprotected forms of tryptophan in ruminants can be a risk. The use of l-tryptophan produced by fermentation using KCCM 80135 in animal nutrition presents no safety concerns to consumers of animal products. l-Tryptophan produced by KCCM 80135 is not toxic by inhalation. The additive is not an irritant to skin and eyes, and it is not a skin sensitiser. The additive under assessment is considered safe for the environment. It is regarded as an effective source of the amino acid l-tryptophan for all non-ruminant species. If the additive l-tryptophan is intended for use in ruminants, it should be protected from ruminal degradation.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就使用KCCM 80135发酵生产的L-色氨酸用作所有动物物种的饲料和饮用水中的营养添加剂提供科学意见。在该添加剂中未检测到生产菌株及其重组DNA。使用KCCM 80135发酵生产的L-色氨酸在生产菌株的基因改造方面不存在任何安全问题。使用KCCM 80135生产的L-色氨酸补充饲料以弥补饲料中色氨酸缺乏对非反刍动物目标物种是安全的。在反刍动物中使用未受保护形式的色氨酸可能存在风险。使用KCCM 80135发酵生产的L-色氨酸用于动物营养对动物产品消费者不存在安全问题。KCCM 80135生产的L-色氨酸吸入无毒。该添加剂对皮肤和眼睛无刺激性，也不是皮肤致敏剂。所评估的添加剂被认为对环境是安全的。它被视为所有非反刍动物物种的氨基酸L-色氨酸的有效来源。如果添加剂L-色氨酸拟用于反刍动物，应防止其在瘤胃中降解。
