Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Costa Lucio, Dierick Noël, Flachowsky Gerhard, Glandorf Boet, Herman Lieve, Mantovani Alberto, Saarela Maria, Wallace Robert John, Anguita Montserrat, Tarrés-Call Jordi, Ramos Fernando
EFSA J. 2019 May 2;17(5):e05695. doi: 10.2903/j.efsa.2019.5695. eCollection 2019 May.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on tryptophan produced by fermentation using KCCM 80152 when used as nutritional additive in feed and water for drinking for all animal species. The production strain and its recombinant DNA were not detected in the additive. Tryptophan, manufactured by fermentation with KCCM 80152, does not give rise to any safety concern with regard to the genetic modification of the production strain. The use of tryptophan produced using KCCM 80152 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non-ruminant target species. Using unprotected forms of tryptophan in ruminants can be a risk. The use of tryptophan produced by fermentation using KCCM 80152 in animal feed presents no concerns to consumers of animal products. Due to the content of endotoxins, the additive poses a risk for persons handling the additive when exposed by inhalation. The additive is not considered irritant for skin or eyes and is not considered a skin sensitiser. The additive under assessment is safe for the environment. The additive under assessment is regarded as an effective source of the amino acid tryptophan for all non-ruminant species. If tryptophan is intended for use in ruminants, it should be protected from ruminal degradation.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就使用KCCM 80152发酵生产的色氨酸作为所有动物物种饲料和饮用水中的营养添加剂提供科学意见。在该添加剂中未检测到生产菌株及其重组DNA。用KCCM 80152发酵生产的色氨酸在生产菌株的基因改造方面不存在任何安全问题。在补充饲料以弥补饲料中色氨酸缺乏时，使用KCCM 80152生产的色氨酸对非反刍目标物种是安全的。在反刍动物中使用未受保护形式的色氨酸可能存在风险。使用KCCM 80152发酵生产的色氨酸作为动物饲料对动物产品消费者不存在问题。由于内毒素含量，该添加剂在被吸入接触时对处理该添加剂的人员构成风险。该添加剂对皮肤或眼睛无刺激性，也不被视为皮肤致敏剂。所评估的添加剂对环境是安全的。所评估的添加剂被认为是所有非反刍物种色氨酸的有效来源。如果色氨酸打算用于反刍动物，应防止其在瘤胃中降解。
