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DJ-1 是一种新的预后标志物，可预测结直肠癌的化疗疗效。

DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer.

机构信息

Department of Oncology, Yixing Hospital Affiliated to the Medical College of Yangzhou University, Yangzhou University, Yixing, Jiangsu 214200, P.R. China.

Institute of Combination of Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.

出版信息

Oncol Rep. 2020 Jul;44(1):77-90. doi: 10.3892/or.2020.7593. Epub 2020 Apr 23.

DOI:10.3892/or.2020.7593
PMID:32627002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7251759/
Abstract

Protein/nucleic acid deglycase DJ‑1 (DJ‑1) is a 20‑kDa conserved protein, which belongs to the DJ‑1/ThiJ/Pfp Ⅰ protein superfamily. Immunohistochemistry was performed to investigate the expression of DJ‑1 in a colorectal cancer (CRC) tissue microarray containing tumor and corresponding adjacent normal tissues. In the present study, DJ‑1 expression was significantly upregulated in CRC cells and tissues, compared with that in normal colon cells and adjacent normal tissues, respectively. In addition, patients with high DJ‑1 expression levels had a worse overall survival (OS) compared with patients with low expression levels. Multivariate Cox regression analysis revealed that high DJ‑1 expression levels was an independent prognostic factor for patients with CRC. Moreover, DJ‑1 was able to regulate the PI3K/Akt/p27/cyclin E and PI3K/Akt/mTOR signaling pathways to promote CRC cell growth and metastasis in vitro and in vivo. In addition, DJ‑1 regulated the NF‑κB/Snail signaling pathway to induce CRC cell epithelial‑mesenchymal transition to promote migration and invasion. Notably, patients receiving LFP treatment (oxaliplatin, 5‑FU and tetrahydrofolate) had an increased OS compared with patients who underwent only surgery and low DJ‑1 expression levels. The findings from the present study suggest that DJ‑1 may serve as a promising prognostic marker and predicts chemotherapy efficacy in patients with CRC.

摘要

蛋白/核酸糖基水解酶 DJ-1（DJ-1）是一种 20kDa 的保守蛋白，属于 DJ-1/ThiJ/PfpⅠ 蛋白超家族。免疫组织化学法用于检测 DJ-1 在包含肿瘤和相应相邻正常组织的结直肠癌（CRC）组织微阵列中的表达。在本研究中，与正常结肠细胞和相邻正常组织相比，DJ-1 在 CRC 细胞和组织中的表达显著上调。此外，DJ-1 高表达的患者总生存期（OS）较 DJ-1 低表达的患者差。多变量 Cox 回归分析显示，DJ-1 高表达是 CRC 患者的独立预后因素。此外，DJ-1 能够调节 PI3K/Akt/p27/cyclin E 和 PI3K/Akt/mTOR 信号通路，促进 CRC 细胞在体外和体内的生长和转移。此外，DJ-1 调节 NF-κB/Snail 信号通路诱导 CRC 细胞上皮-间充质转化，促进迁移和侵袭。值得注意的是，接受 LFP 治疗（奥沙利铂、5-FU 和四氢叶酸）的患者的 OS 较仅接受手术和 DJ-1 低表达的患者增加。本研究的结果表明，DJ-1 可能作为一种有前途的预后标志物，预测 CRC 患者的化疗疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/6f453c8b5a3b/OR-44-01-0077-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/e87317dd1a4c/OR-44-01-0077-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/465f3565cb3d/OR-44-01-0077-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/24e7ad304f4b/OR-44-01-0077-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/548f1f1e1d46/OR-44-01-0077-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/4e999aaf96f0/OR-44-01-0077-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/30009c45f105/OR-44-01-0077-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/6f453c8b5a3b/OR-44-01-0077-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/e87317dd1a4c/OR-44-01-0077-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/465f3565cb3d/OR-44-01-0077-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/24e7ad304f4b/OR-44-01-0077-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/548f1f1e1d46/OR-44-01-0077-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/4e999aaf96f0/OR-44-01-0077-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/30009c45f105/OR-44-01-0077-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422d/7251759/6f453c8b5a3b/OR-44-01-0077-g07.jpg

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