Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
J Food Biochem. 2021 Mar;45(3):e13355. doi: 10.1111/jfbc.13355. Epub 2020 Jul 6.
Mushrooms have been reported in folklore for the management of Alzheimer's disease (AD) and diabetes with limited scientific prove. This study aims to unravel the effect of diets supplemented with P. ostreatus and L. subnudus on diabetic encephalopathy (DE) in streptozotocin (STZ)-induced diabetic rats. The memory index, brain cholinesterase, arginase activity, and markers for oxidative stress were evaluated. STZ-induced diabetic rats exhibited memory deficits, elevated brain cholinesterase, arginase activity in comparison with nondiabetic rats. Also, markers for oxidative stress were altered in the brain of diabetic rat when compare with nondiabetic rats. Meanwhile, diabetic rats fed with supplemented-diets exhibited better memory index, reduced cholinesterase, arginase activity in comparison with untreated diabetic rats placed on a basal diet. Also, supplemented-diets restored altered markers of oxidative stress. Our findings indicated that P. ostreatus and L. subnudus-supplemented diets could prevent DE. Nevertheless, diets supplemented with L. subnudus had better nutraceutical potential than P. ostreatus. PRACTICAL APPLICATIONS: Diabetes mellitus is one of the most chronic diseases in the world. Also, it is a risk factor for several complications such as cognitive dysfunction, hypertension, and other health issues. Mushrooms are commonly consumed as food or as food supplements in many countries of the world and are a rich source of protein, chitin, and vitamins. Diet supplemented with P. ostreatus and L. subnudus were able to restore memory deficit in diabetic rats, proven to be a dietary intervention in the management of memory deficit linked with diabetes mellitus. Findings from this study show that consumption of P. ostreatus and L. subnudus as food or supplement could help in a diabetic state.
蘑菇在民间传说中被用于治疗阿尔茨海默病 (AD) 和糖尿病，但科学证据有限。本研究旨在揭示补充糙皮侧耳 (P. ostreatus) 和亚侧耳 (L. subnudus) 饮食对链脲佐菌素 (STZ) 诱导的糖尿病大鼠糖尿病性脑病 (DE) 的影响。评估了记忆指数、脑胆碱酯酶、精氨酸酶活性和氧化应激标志物。与非糖尿病大鼠相比，STZ 诱导的糖尿病大鼠表现出记忆缺陷、脑胆碱酯酶升高和精氨酸酶活性升高。此外，与非糖尿病大鼠相比，糖尿病大鼠大脑中的氧化应激标志物也发生了改变。同时，与未接受治疗的糖尿病大鼠相比，补充饮食的糖尿病大鼠表现出更好的记忆指数、降低的胆碱酯酶和精氨酸酶活性。补充饮食还恢复了改变的氧化应激标志物。我们的研究结果表明，糙皮侧耳和亚侧耳补充饮食可以预防 DE。然而，与糙皮侧耳相比，补充亚侧耳的饮食具有更好的营养保健品潜力。 实际应用：糖尿病是世界上最常见的慢性疾病之一。此外，它也是许多并发症的危险因素，如认知功能障碍、高血压和其他健康问题。在世界上许多国家，蘑菇作为食物或食品补充剂被广泛食用，是蛋白质、几丁质和维生素的丰富来源。补充糙皮侧耳和亚侧耳的饮食能够恢复糖尿病大鼠的记忆缺陷，被证明是一种饮食干预措施，可用于治疗与糖尿病相关的记忆缺陷。本研究的结果表明，食用糙皮侧耳和亚侧耳作为食物或补充剂可能有助于糖尿病状态。
