Trams Ewa, Kulinski Krzysztof, Kozar-Kaminska Katarzyna, Pomianowski Stanislaw, Kaminski Rafal
Department of Orthopaedics and Trauma Surgery, Centre of Postgraduate Medical Education, Professor A. Gruca Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland.
Department of Medical Biology, Stefan Cardinal Wyszynski National Institute of Cardiology, ul. Alpejska 42, 04-628 Warsaw, Poland.
Life (Basel). 2020 Jun 25;10(6):94. doi: 10.3390/life10060094.
In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of knee disorders and during knee surgery has exponentially increased over the last decade. A systematic review with meta-analyses was performed by assessing selected studies of local PRP injections to the knee joint. The study was completed in accordance with 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A multistep search of PubMed, Embase, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov was performed to identify studies on knee surgery and knee lesion treatment with PRP. Of the 4004 articles initially identified, 357 articles focusing on knee lesions were selected and, consequently, only 83 clinical trials were analyzed using the revised Cochrane risk-of-bias tool to evaluate risk. In total, seven areas of meta-analysis reported a positive effect of PRP. Among them, 10 sub-analyses demonstrated significant differences in favor of PRP when compared to the control groups ( < 0.05). This study showed the positive effects of PRP, both on the recovery of knee disorders and during knee surgery; however further prospective and randomized studies with a higher number of subjects and with lower biases are needed.
近年来，人们对膝关节损伤生物治疗的兴趣有所增加，尤其是富含血小板血浆的应用格外引人注目。在过去十年中，评估富含血小板血浆（PRP）在膝关节疾病恢复及膝关节手术中疗效的文章数量呈指数级增长。通过评估对膝关节进行局部PRP注射的选定研究，进行了一项系统评价和荟萃分析。该研究按照2009年《系统评价和荟萃分析的首选报告项目》（PRISMA）声明完成。对PubMed、Embase、Cochrane系统评价数据库和Clinicaltrials.gov进行了多步骤检索，以确定有关PRP用于膝关节手术和膝关节损伤治疗的研究。在最初识别出的4004篇文章中，选择了357篇关注膝关节损伤的文章，因此，仅使用修订后的Cochrane偏倚风险工具对83项临床试验进行了分析以评估风险。总共，七个荟萃分析领域报告了PRP的积极作用。其中，10项亚分析表明，与对照组相比，PRP具有显著差异（<0.05）。本研究显示了PRP在膝关节疾病恢复及膝关节手术中的积极作用；然而，需要进行更多受试者数量更多、偏倚更低的前瞻性随机研究。
