Signini Étore F, Nieman David C, Silva Claudio D, Sakaguchi Camila A, Catai Aparecida M
Physical Therapy Department, Federal University of São Carlos, São Carlos, SP 13565-905, Brazil.
North Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA.
Metabolites. 2020 Jun 25;10(6):264. doi: 10.3390/metabo10060264.
Oxylipins are oxidized compounds of polyunsaturated fatty acids that play important roles in the body. Recently, metabololipidomic-based studies using advanced mass spectrometry have measured the oxylipins generated during acute and chronic physical exercise and described the related physiological effects. The objective of this systematic review was to provide a panel of the primary exercise-related oxylipins and their respective functions in healthy individuals. Searches were performed in five databases (Cochrane, PubMed, Science Direct, Scopus and Web of Science) using combinations of the Medical Subject Headings (MeSH) terms: "Humans", "Exercise", "Physical Activity", "Sports", "Oxylipins", and "Lipid Mediators". An adapted scoring system created in a previous study from our group was used to rate the quality of the studies. Nine studies were included after examining 1749 documents. Seven studies focused on the acute effect of physical exercise while two studies determined the effects of exercise training on the oxylipin profile. Numerous oxylipins are mobilized during intensive and prolonged exercise, with most related to the inflammatory process, immune function, tissue repair, cardiovascular and renal functions, and oxidative stress.
氧化脂质是多不饱和脂肪酸的氧化产物，在体内发挥着重要作用。最近，基于代谢脂质组学的研究使用先进的质谱技术测量了急性和慢性体育锻炼过程中产生的氧化脂质，并描述了相关的生理效应。本系统综述的目的是提供一组主要的与运动相关的氧化脂质及其在健康个体中的各自功能。使用医学主题词（MeSH）术语的组合在五个数据库（Cochrane、PubMed、Science Direct、Scopus和Web of Science）中进行检索：“人类”、“运动”、“身体活动”、“体育”、“氧化脂质”和“脂质介质”。我们小组之前一项研究中创建的一个经过调整的评分系统用于评估研究的质量。在审查了1749份文献后纳入了9项研究。7项研究关注体育锻炼的急性效应，而2项研究确定了运动训练对氧化脂质谱的影响。在高强度和长时间运动过程中，大量氧化脂质被调动起来，其中大多数与炎症过程、免疫功能、组织修复、心血管和肾功能以及氧化应激有关。
