Osher Center for Integrative Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Integr Complement Med. 2024 Sep;30(9):897-901. doi: 10.1089/jicm.2024.0233. Epub 2024 Jul 15.
Yoga may promote health via a complex modulation of inflammation. Little is known about oxylipins, a class of circulating mediators involved in inflammation resolution. To explore the acute effects of yoga exercise on systemic levels of oxylipins. This is a secondary analysis of a three-arm (high-intensity-yoga: HY, = 10); moderate-intensity-yoga: MY, = 10; and no-intervention-control: CON, = 10) pilot randomized controlled trial employing a single bout of yoga exercise. Blood samples (baseline and 4-timepoint post-intervention) were used for an unbiased metabolipidomic profiling analysis. Net Areas Under the Curve per oxylipin were evaluated for each group. Lipoxin(LX)B4, prostaglandin(PG)D2, and resolvin(Rv)D3 exhibited a greater magnitude of change in HY compared with MY and CON. Findings inform the design of future trials exploring the acute effects of yoga exercise on oxylipins' systemic levels.
瑜伽可能通过对炎症的复杂调节来促进健康。人们对参与炎症消退的一类循环介质——氧化脂质知之甚少。本研究旨在探讨瑜伽运动对全身性氧化脂质水平的急性影响。这是一项三臂（高强度瑜伽：HY，n=10；中强度瑜伽：MY，n=10；无干预对照组：CON，n=10）随机对照试验的二次分析，采用单次瑜伽运动干预。利用血液样本（基线和干预后 4 个时间点）进行无偏代谢脂质组学分析。对每组的每个氧化脂质的净曲线下面积进行评估。与 MY 和 CON 相比，脂氧素（LX）B4、前列腺素（PG）D2 和分辨率（Rv）D3 变化幅度更大。研究结果为未来探索瑜伽运动对氧化脂质全身性水平的急性影响的试验设计提供了信息。
