Poznyak Anastasia V, Ivanova Ekaterina A, Sobenin Igor A, Yet Shaw-Fang, Orekhov Alexander N
Department of Basic Research, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.
Laboratory of Medical Genetics, National Medical Research Center of Cardiology, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia.
Biology (Basel). 2020 Jun 25;9(6):137. doi: 10.3390/biology9060137.
The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a central player in the regulation of cellular metabolism and a powerful controller of cellular fate, mitochondria appear to comprise an interesting potential therapeutic target. With the development of DNA sequencing methods, mutations in mitochondrial DNA (mtDNA) became a subject of intensive study, since many directly lead to mitochondrial dysfunction, oxidative stress, deficient energy production and, as a result, cell dysfunction and death. Many mtDNA mutations were found to be associated with chronic human diseases, including cardiovascular disorders. In particular, 17 mtDNA mutations were reported to be associated with ischemic heart disease in humans. In this review, we discuss the involvement of mitochondrial dysfunction in the pathogenesis of atherosclerosis and describe the mtDNA mutations identified so far that are associated with atherosclerosis and its risk factors.
线粒体在心血管疾病中的作用正受到越来越多的关注。作为细胞代谢调节的核心参与者和细胞命运的有力掌控者，线粒体似乎构成了一个有趣的潜在治疗靶点。随着DNA测序方法的发展，线粒体DNA（mtDNA）突变成为深入研究的对象，因为许多此类突变会直接导致线粒体功能障碍、氧化应激、能量产生不足，进而导致细胞功能障碍和死亡。人们发现许多mtDNA突变与包括心血管疾病在内的慢性人类疾病有关。特别是，据报道有17种mtDNA突变与人类缺血性心脏病有关。在这篇综述中，我们讨论了线粒体功能障碍在动脉粥样硬化发病机制中的作用，并描述了迄今为止已确定的与动脉粥样硬化及其危险因素相关的mtDNA突变。
