Simpson K H, Halsall P J, Carr C M, Stewart K G
University Department of Anaesthesia, St James's University Hospital, Leeds, Yorks.
Br J Anaesth. 1988 Sep;61(3):343-4. doi: 10.1093/bja/61.3.343.
Twenty-five patients received either methohexitone 1.0 mg kg-1 or propofol 1.3 mg kg-1 to induce anaesthesia during two separate electroconvulsive therapy (ECT) treatments. A forearm was isolated before administration of suxamethonium 0.5 mg kg-1, so that unmodified seizure duration could be measured. Bifrontotemporal electrodes were applied to administer a standard 3-s ECT shock. Median (quartile deviation) duration of seizure was reduced significantly after propofol (19.0 (9.0) s), compared with after methohexitone (33.0 (7.8) s). Therefore propofol may not be an appropriate anaesthetic for ECT because of its adverse effect on seizure duration.
25名患者在两次单独的电休克治疗（ECT）中分别接受1.0毫克/千克的美索比妥或1.3毫克/千克的丙泊酚以诱导麻醉。在给予0.5毫克/千克的琥珀酰胆碱之前分离出一只前臂，以便能够测量未改变的癫痫发作持续时间。应用双额颞电极给予标准的3秒ECT电击。与美索比妥给药后（33.0（7.8）秒）相比，丙泊酚给药后癫痫发作的中位（四分位数偏差）持续时间显著缩短（19.0（9.0）秒）。因此，丙泊酚可能不是ECT的合适麻醉剂，因为它对癫痫发作持续时间有不良影响。
