Dwyer R, McCaughey W, Lavery J, McCarthy G, Dundee J W
Department of Anaesthetics, Craigavon Area Hospital, Armagh.
Anaesthesia. 1988 Jun;43(6):459-62. doi: 10.1111/j.1365-2044.1988.tb06631.x.
Propofol was compared to methohexitone for induction of anaesthesia for electroconvulsive therapy. Seizures were significantly shorter after the use of propofol, in respect of both visible seizures and duration of cerebral electrical seizure activity. This suggests the possibility that additional treatments may be needed for the same clinical effect in psychiatric illness when propofol is used as the induction agent. Propofol was more effective than methohexitone at obtunding the hypertensive response to electroconvulsive therapy without causing significant hypotension.
将丙泊酚与甲己炔巴比妥用于电休克治疗的麻醉诱导进行比较。使用丙泊酚后，无论是可见癫痫发作还是脑电癫痫活动持续时间，癫痫发作都显著缩短。这表明，当使用丙泊酚作为诱导剂时，在精神疾病中为达到相同临床效果可能需要额外的治疗。在减轻电休克治疗引起的高血压反应方面，丙泊酚比甲己炔巴比妥更有效，且不会引起显著低血压。
