探索远处转移的途径。
Navigating the path to distant metastasis.
机构信息
Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Arizona Centre for Cancer Evolution (ACE), Arizona State University, Tempe, AZ, USA.
出版信息
Nat Genet. 2020 Jul;52(7):642-643. doi: 10.1038/s41588-020-0660-z.
Abstract
How ‘difficult’ is it for somatic evolution to produce a cell that is capable of leaving the primary tumor and growing in a distant organ? In this issue, Reiter et al. assess genetic diversity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.
摘要
体细胞进化产生能够离开原发肿瘤并在远处器官生长的细胞的难度有多大？在本期杂志中，Reiter 等人评估了转移病灶中的遗传多样性，并在远处转移前确定了一个紧密的选择性瓶颈。
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