Repo H, Leirisalo-Repo M, Koskimies S
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Clin Exp Rheumatol. 1988 Jul-Sep;6(3):227-31.
Sera from both HLA-B27 positive patients with previous yersinia arthritis and healthy HLA-B27 positive subjects have been reported to stimulate chemokinetic migration of polymorphonuclear leukocytes (PMNs) more than sera from subjects who are HLA-B27 negative. To study this further we tested chemotactic and chemokinetic activities of sera of 213 consecutive blood donors (27 positive for HLA-B27, 12.7%) and those of 55 children (mean age 20 months, range 6-137 months, 8 positive for HLA-B27, 14.5%). Migration distances of PMNs both in membrane filter and under agarose were longer, although not in a statistically significant way, in HLA-B27 positive adult sera than in HLA-B27 negative ones. Chemokinetic activity of sera of HLA-B27 positive children was very similar to that of HLA-B27 negative children. These results give credence to the view that PMN migration enhancing capacity of HLA-B27 positive sera described previously is acquired secondarily and is not genetically determined.
据报道，与HLA - B27阴性受试者的血清相比，既往有耶尔森菌关节炎的HLA - B27阳性患者和健康的HLA - B27阳性受试者的血清更能刺激多形核白细胞（PMN）的化学动力学迁移。为了进一步研究这一现象，我们检测了213名连续献血者（27名HLA - B27阳性，占12.7%）和55名儿童（平均年龄20个月，范围6 - 137个月，8名HLA - B27阳性，占14.5%）血清的趋化和化学动力学活性。在膜滤器和琼脂糖下，HLA - B27阳性成人血清中PMN的迁移距离比HLA - B27阴性血清中的迁移距离更长，尽管差异无统计学意义。HLA - B27阳性儿童血清的化学动力学活性与HLA - B27阴性儿童的非常相似。这些结果支持了以下观点：先前所述HLA - B27阳性血清增强PMN迁移的能力是继发获得的，而非由基因决定。
