多形核白细胞功能与既往耶尔森菌关节炎：超氧化物生成增强与晚期表现的相关性。
Polymorphonuclear leucocyte function and previous yersinia arthritis: correlation of enhanced superoxide production with late manifestations.
作者信息
Repo H, Koivuranta-Vaara P, Leirisalo-Repo M
机构信息
Department of Bacteriology and Immunology, University of Helsinki, Finland.
出版信息
Ann Rheum Dis. 1988 Jun;47(6):452-7. doi: 10.1136/ard.47.6.452.
Abstract
Polymorphonuclear leucocyte (PMN) functions (migration in vitro, chemiluminescence, O-2 production, and aggregation) were studied in 32 patients with previous yersinia arthritis (YA). PMNs of 11 HLA-B27 positive patients who had chronic or recurrent inflammatory symptoms showed O-2 production significantly higher than that of PMNs of 11 HLA-B27 positive patients without late manifestations. Also, PMNs of both HLA-B27 positive and negative patients tended to show chemotactic and chemokinetic migration rates higher than those of control cells of healthy HLA-B27 negative subjects. These functional aberrations may play a part in the development of the patients' inflammatory symptoms.
摘要
对32例曾患耶尔森菌关节炎（YA）的患者的多形核白细胞（PMN）功能（体外迁移、化学发光、O₂生成和聚集）进行了研究研究研究。11例有慢性或复发性炎症症状的HLA - B27阳性患者的PMN的O₂生成显著高于11例无晚期表现的HLA - B27阳性患者的PMN。此外，HLA - B27阳性和阴性患者的PMN趋化和化学动力学迁移率均倾向于高于健康HLA - B27阴性受试者的对照细胞。这些功能异常可能在患者炎症症状的发展中起作用。
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本文引用的文献
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Arthritis Rheum. 1980 Sep;23(9):1036-44. doi: 10.1002/art.1780230911.
2
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Arthritis Rheum. 1982 Jun;25(6):655-61. doi: 10.1002/art.1780250608.
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