HLA B27阳性受试者体内中性粒细胞迁移增强。
Enhanced neutrophil migration in vivo HLA B27 positive subjects.
作者信息
Koivuranta-Vaara P, Repo H, Leirisalo M, Kiistala U, Osterman T, Vapaatalo H
出版信息
Ann Rheum Dis. 1984 Apr;43(2):181-5. doi: 10.1136/ard.43.2.181.
Abstract
Chemotaxis of polymorphonuclear leucocytes in vivo was studied in patients with previous yersinia arthritis and in healthy subjects with or without HLA B27 by means of a skin chamber technique. Irrespective of previous arthritis the number of neutrophils in the chamber media was significantly higher in HLA B27 positive subjects than in those without HLA B27. The amounts of prostaglandins E2, F2 alpha, and 6-keto-F1 alpha in the chamber media correlated positively with the corresponding cell counts. The present results give credence to the view that the hyperreactive neutrophils and the vasodilatory prostaglandins produced by them can together trigger a vicious circle which results in increased inflammatory symptoms in patients with yersinia arthritis who have HLA B27 as compared with those who lack this antigen.
摘要
采用皮肤腔室技术，对既往有耶尔森菌关节炎的患者以及有或无HLA - B27的健康受试者体内多形核白细胞的趋化性进行了研究。无论既往是否患有关节炎，HLA - B27阳性受试者腔室培养基中的中性粒细胞数量均显著高于无HLA - B27的受试者。腔室培养基中前列腺素E2、F2α和6 - 酮 - F1α的含量与相应的细胞计数呈正相关。目前的结果支持这样一种观点，即反应性过高的中性粒细胞及其产生的血管舒张性前列腺素可共同引发恶性循环，导致与缺乏该抗原的患者相比，患有耶尔森菌关节炎且有HLA - B27的患者炎症症状加重。
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