Meram Faculty of Medicine, Department of Ophthalmology, Necmettin Erbakan University, 42080, Meram, Konya, Turkey.
Int Ophthalmol. 2020 Nov;40(11):2979-2986. doi: 10.1007/s10792-020-01481-7. Epub 2020 Jul 6.
To investigate microstructural changes in the macular inner retinal layers over time in the fellow eyes of patients with unilateral central retinal artery occlusion (CRAO).
Spectral-domain optical coherence tomography scans of 16 patients with CRAO were performed at initial examination (1st day), at 1st month, at 3rd month, at 6th month, and the central macular thickness (CMT) and inner retinal layer thicknesses in the fellow eyes of the patients were compared between each visit. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL) were calculated in 9 quadrants according to the definition by the Early Treatment Diabetic Retinopathy Study.
CMT decreased over a 6-month period, but the difference was insignificant among visits (p = 0.072). Also, there were no significant differences in the thicknesses of RNFL and GCL among visits (p > 0.05 for all quadrants). But there was thinning in the parafoveal superior and perifoveal superior quadrants of the IPL (p = 0.007, p = 0.01) and in the parafoveal temporal quadrant of the INL (p = 0.033) within 6 months of follow-up in the fellow eyes of the patients with CRAO.
This study demonstrated subclinical alterations of the macular inner retinal layers over time in the fellow eyes of CRAO patients.
研究单侧视网膜中央动脉阻塞（CRAO）患者对侧眼黄斑内层视网膜微观结构随时间的变化。
对 16 例 CRAO 患者进行频域光相干断层扫描，分别于初次检查（第 1 天）、第 1 个月、第 3 个月、第 6 个月进行检查，并比较患者对侧眼的中央黄斑厚度（CMT）和内层视网膜厚度。根据早期糖尿病视网膜病变研究的定义，在 9 个象限中计算视网膜神经纤维层（RNFL）、节细胞层（GCL）、内丛状层（IPL）和内核层（INL）的厚度。
CMT 在 6 个月内逐渐下降，但各次随访之间差异无统计学意义（p=0.072）。此外，RNFL 和 GCL 的厚度在各次随访之间也无显著差异（所有象限 p>0.05）。但是，在 CRAO 患者对侧眼的 IPL 旁中心上象限和旁中心上象限以及 INL 旁中心颞象限的厚度在 6 个月的随访中变薄（p=0.007，p=0.01）。
本研究表明，CRAO 患者对侧眼的黄斑内层视网膜随时间发生亚临床改变。
