National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing Collaborative Innovation Center of Targeted and Innovative Therapeutics, College of Pharmacy & IATTI, Chongqing University of Arts and Sciences, Chongqing, 402160, P.R. China.
ACS Comb Sci. 2020 Sep 14;22(9):468-474. doi: 10.1021/acscombsci.0c00105. Epub 2020 Jul 21.
An efficient one-pot multicomponent reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-]pyridines starting from readily available cinnamaldehydes, ethylenediamines, and 1,3-dicarbonyl compounds catalyzed by AcOH is described. Two new cycles and four new bonds are constructed with all reactants being efficiently utilized in this transformation. The products could be obtained in 1-3 h under ambient conditions exclusively as a single isomer (trans). Single-crystal X-ray analysis confirmed the trans derivative as the only isomer.
描述了一种从肉桂醛、乙二胺和 1,3-二羰基化合物出发，在 AcOH 催化下高效一锅法合成新型四取代六氢咪唑并[1,2-a]吡啶的多组分反应。两个新环和四个新键在这个转化中都用所有反应物有效地构建起来。在环境条件下，仅作为单一异构体（反式），产物可在 1-3 h 内获得。单晶 X 射线分析证实反式衍生物是唯一的异构体。
